PhD Student

The polarized cell shows zones of forward migration – protruding edges – and zones where the cell reduces its surface, retracting edges.

These processes are only possible due to the flexibility of the cytoskeleton, which is mainly driven by the two major components: actin filaments and microtubules (MTs).

Actin filaments are responsible to enable processes such as protrusion, adhesion and retraction, whereas MTs are important in establishing cell polarization and are considered to play a crucial role in directed migration.

The the aim of my project is, to further characterize the different aspects of the organization of the MT cytoskeleton and the dynamics of MTs in dendritic cells to enhance our understanding of how these cytoskeletal components contribute to the establishment of cell polarity and motility.

 

 

Institute of Science and Technology Austria

Bertalanffy Foundation Building (2nd floor, I04)

Am Campus 1

A-3400 Klosterneuburg

+43 2243 9000 3802

aglaja.kopf@ist.ac.at