PhD student

Metastases of carcinomas form initially in regional lymph nodes and subsequently in distant organs. The active role of lymph nodes during systemic spread to vital organs is highly debated, however recent clinical studies highlight the importance of targeting metastatic lymph nodes to treat distant disease.

The first tumor cells residing in the lymph node form small aggregates in the marginal lymph node sinus, are attached to subcapsular sinus (SCS) lining endothelial cells and fibroblastic reticular cells and gradually invade the lymph node’s parenchyma. The mechanisms by which intranodal tumor cells seed the SCS, invade the parenchyma and intravasate the specialised blood and lymphatic vessels of the lymph node are currently unknown.

My research aims to shed light on these processes that promise to be highly relevant for clinical management of cancer patients.

 

Bertalanffy Foundation Building (2nd floor, I04)

Am Campus 1

A-3400 Klosterneuburg


markus.brown@ist.ac.at