Jozsef Csicsvari works in the field of systems neuroscience. The Csicsvari group focuses on the hippocampus, a brain area known to be important for memory formation, and aims to understand how learning leads to memory formation. During learning, memory traces are processed and encoded in neuronal circuits and consolidated for later recall. The group seeks to understand how neuronal circuits process such learning-related information and form memory by recording the activity of many neurons in different brain circuits during learning tasks and sleep. They use a technique called ‘multi-channel extracellular recording’ which monitors the electrical activity of many neurons in different brain circuits in behaving rodents. This work involves the use of sophisticated microelectrode arrays (e.g. silicon microelectrodes) during complex behavioural tasks. In addition, optogenetic methods are used to selectively manipulate neuronal activity in the hippocampus. Different learning tasks allow the researchers to investigate the mnemonic coding of neuronal assemblies and the role of oscillatory activity during encoding, consolidation and recall of mnemonic information. Memory consolidation requires the hippocampus to interact with other cortical regions, and the Csicsvari group investigates whether and how synchronous oscillations between the hippocampus and the entorhinal cortex facilitate consolidation and the ultimate storage of memories. The large volume of complex electrophysiological data collected in these experiments requires sophisticated computer analysis techniques as well as the development of new computational analysis techniques.
Institute of Science and Technology Austria (IST Austria)
Am Campus 1
A – 3400 Klosterneuburg
Phone: +43 (0)2243 9000-4301
E-mail: jozsef.csicsvari@ ist.ac.at
Phone: +43 (0)2243 9000-1096
E-mail: dana.domnisor@ ist.ac.at
- Peter Baracskay, Postdoc
- Igor Gridchyn, PhD Student
- Agnes Hermann, Intern
- Karola Käfer, PhD student
- Joseph O'Neill, Postdoc
- Damaris Rangel Guerrero, PhD Student
- Federico Stella, Postdoc
- Jago Wallenschus, Technician
- Haibing Xu, PhD Student
- Oscillatory interactions in working memory
- Role of hippocampal formation in spatial learning
- Activation of brain structures using light sensitive channels to study memory formation
- Dupret D, O'Neill J, Csicsvari J. 2013. Dynamic reconfiguration of hippocampal interneuron crucits during spatial learning. Neuron, 78:166-80.
- Dupret D, O’Neill J, Pleydell-Bouverie B, Csicsvari J.2010. The reorganization and reactivation of hippocampal maps predict spatial memory performance. Nature Neurosci., 13: 995-1002.
- O’Neill J, Senior TJ, Allen K, Huxter JR, Csicsvari J. 2008. Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neurosci. 11:209-215.
Since 2011 Professor, IST Austria
2008–2011 MRC Senior Scientist (tenured), MRC Anatomical Neuropharmacology Unit, University of Oxford, UK
2003–2008 MRC Senior Scientist (tenure-track), MRC Anatomical Neuropharmacology Unit, University of Oxford, UK
2001–2002 Research Associate, Center for Behavioral and Molecular Neuroscience, Rutgers University, USA
1999–2001 Postdoctoral Fellow, Center for Behavioral and Molecular Neuroscience, Rutgers University, USA
1993–1999 Graduate Assistant, Center for Behavioral and Molecular Neuroscience, Rutgers University, USA
1999 PhD, Rutgers University, USA
2011 ERC Starting Grant
2010 Title of Ad Hominem Professor in Neuroscience at the University of Oxford