Oct 20, 2020

Towards quantitative structural cell biology: in situ experiments and simulations discover flexible hinges in SARS-CoV-2 Spike protein.

MoPS series talk

Date: October 20, 2020 | 2:00 pm – 3:00 pm
Speaker: Mateusz Sikora, Max Planck Institute, Frankfurt
Location: via Zoom

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein mediates viral entry to the host cells and initiates the infection. As the only exposed surface protein, it is a primary target for vaccine development. We combined cryo-electron tomography, subtomogram averaging, and molecular dynamics simulations to visualise and structurally characterise spike proteins on the surface of intact virions. We discover three hinges in the stalk of S protein that endow it with surprising flexibility and can be relevant in the process of binding to the surface of the host cell.

 

More Information:

Date:
October 20, 2020
2:00 pm – 3:00 pm

Speaker:
Mateusz Sikora, Max Planck Institute, Frankfurt

Location:
via Zoom

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