MAX PLANCK INSTITUTE FOR EVOLUTIONARY ANTHROPOLOGY, LEIPZIG, GERMANY
Harald Ringbauer was a PhD student in the Nick Barton group. He is now a group leader at the Max Planck Institute for Evolutionary Anthropology, Leipzig. In January 2021 he visited the IST Austria campus to take a walk down memory lane and answer some questions about his work and career.
My business card right now says group leader at the Max Planck Institute for archaeogenetics in Leipzig, and I actually adjusted to get a new business card. Because up until now, I was doing a postdoc at Harvard, at the Harvard Medical School. I will actually keep my affiliation. So it will be a pretty cool business card.
I’m an archaeogeneticist, which means that we get DNA from human remains who lived 1000s of years ago. And then, we look at how people moved around, how they’re related, and their social structure. So we try to get insight into past movement into past mobility into past patterns, how we live together. The coolest thing is that you really get fascinating insights of people who lived like 1000s of years ago, and it’s still mind-boggling for me. For instance, Ötzi: We have his whole genome, and you can really see to whom he is related and how he came there. We can see from which group he was if his parents were related. So, the coolest thing about my job is that you really get fascinating new insights into who these past people were.
The limitations are that, when we look at the human past, this is often a very emotionally very loaded topic. So often, even when you don’t even think about it. When we only tell stories about past movements or stories about ancestry. People with certain agendas try to take these results and make an argument out of them. So you always have to be careful not to step on anyone’s toes, and also to present it in a very sensible way.
Totally in science. So normal will be for five years at the Max Planck Institute as a group leader. I hope to see myself in five years in Leipzig. And then beyond that: a career in science. Actually, long run, I like humans. They are very interesting for doing ancient DNA. But now we can also do ancient DNA on animals and dogs, on horses, and so on. So that would actually go full circle for the PhD doing genetic analysis, and I want to stay in that kind of topic.
In my bachelor’s and master’s, I did mathematics and physics at the University of Vienna, so actually very abstract. And then only at the IST, I came, I became more interested in actually population genetics, where you can actually apply these mathematical tools to population genetics, and then became more and more interested in actual data analysis. And so, in the US, I really dove deep into archaeogenetics. That’s actually a very interesting story. Because before I started, I was actually thinking: history or mathematics. Because actually, I had a big interest in human history. But I chose mathematics. And I would not have guessed that, actually, by choosing to study mathematics, I would end up with an academic position in archaeology and human history. And it’s really funny to see like this way of quantitative thinking and like this modeling is now actually very useful in really like figuring out, really old big archaeological questions about the human prehistory and also now about human history.
It was the first time I came into contact with world-class population genetics. I was really lucky to have my supervisor Nick Barton, who is like a world-renowned expert, and I really came into contact with bleeding-edge science, like meeting the experts in the field. I got really good training in that and a lot of expertise. Up until now, I think this is the skill set and the network. I think that it is absolutely the key to my career.
The first piece of advice is: Don’t listen to advice. Go your own way. It’s like sciences. There are many aspects. It’s different for anyone, like it’s different per field it is different per character. There are actually many paths to success, and everyone has to find their own way, tailored to their own strength.
But then the second one, you should actually listen to that one: hard work and patience. It’s often not easy in science. You have to keep going. Everyone has good and bad days. It’s totally normal to have bad days, but persistence is important.
The third one is: don’t forget to have fun. You have to find a good balance. It was really good to play table soccer and getting everything out of the system. Most of us are not robots, and most of us, you know, work best when we have a good balance.
Great moments were certainly coming to the bridge after lunch and seeing everyone, my cohort, my international group of friends, having fun on the bridge having fun talking. So many fun moments: Playing table soccer, going to the sauna! All our retreats! Just sitting outside on the balcony. Coming back here to IST, it’s actually all coming back to me. Actually, I am thinking of doing another PhD at IST. 😉
Christine Moussion was a Postdoc at IST Austria. She now works as a group leader for Genentech in Califonia. At IST Austria Christine Moussion was in Michael Sixt’s group.
In an interview with Daniela Klammer and Kathrin Pauser which took place during the Science and Industry Day 2018 she answered some interesting questions about her work and how her career developed.
On my business card is my first name and my last name, my position: I am a scientist in cancer immunology at Genentech in San Francisco, my address and my phone number. 😉
I lead a research team in a big pharma company I work in basic science and in the same time I lead 3 to 4 people in the basic science and at the same time I do some drug discovery at the same time. I think the coolest thing about my job is it is all about science. Basic science or applied science so to develop new treatment and also that there is no limitation. So we can do whatever we want in term of support facilities money so I think it is really to have great science and great support.
In the future I think I will go where the science will bring me. All I have worked for now is where I am happy to work on and I hope I can contribute to the development of new treatment for disease and at the same time make great basic science discoveries. And have fun in science.
I trained as a bioengineer in biotechnology and I worked for a short time in a start up in drug development. Then I came back to university because I decided to step back and to learn a new field which was immunology which I got very passionate about. So I did a PhD in immunology and a postdoc at IST Austria in Michael Sixt’s lab. I worked at the migration of leucocytes and developed a new bio imaging technic and assets that I can now apply in my current job. So I looked at immune cells recruitment in tumor and how to stimulate the recruitment of this leucocytes to improve cancer immune therapy.
IST Austria gave me the freedom to explore science the edges of science of my field like working at the interfaces between immunology and bio imaging for example. The platform of bioimaging is amazing and is always stimulating the progress, the development of new techniques. My mentor played the biggest role. He gave me freedom and he gave me support in terms of looking for jobs by connecting with his network and confidence.
IST was my first international experience. So I learned English here because I came from France. So now that I am living in the US the Americans say that I am speaking with a German accent. I am not sure about that I think I still have a strong French accent. Here I connected with a different type of culture and a different kind of science, really multidisciplinary, so I connected with Mathematicians or physicists and that’s what I liked at IST.
If I rely on my experience I would say: follow the science. See where the science will bring you. But take action you are the actor of your career. You have to make decisions if you need to step back if you need to change direction. You have to keep being proactive. Work hard surely for papers. Papers can get you everywhere. Go to conferences, connect to the leaders in your field to see where your field is moving and it’s also easier if you want to work in industry if you already know people working there. So if people know you and they know your way of thinking and the science you want to develop it is easier to get in later on. Chose a good mentor, a supportive mentor is crucial for a great future job.
I have two probably. When I was living in the guest house and also later I was able to cook French recipes and I was able to share French food with my colleges and I could learn recipes from different cuisine like Indian and I loved that a lot. And I also loved the postdoc retreat when we were going to the mountain for skiing. I think that were the two moments where I connected and I made really good friends, really strong connections. So that is probably my favorite moment at IST.
MAX PLANCK INSTITUTE FOR INTELLIGENT SYSTEMS, TÜBINGEN, GERMANY
Michal Rolinek was a PhD student at IST Austria. He now works as a postdoc at the Max Plank Institute for Intelligent Systems. At IST Austria Michal Rolinek was in the Kolmogorv Group.
He returned to campus as a speaker at the Science Industry Day 2018 and found the time to give an interview and answer some interesting questions about his work.
I don’t have a business card but if I had one it would say that I am a postdoc at the Max Plank Institute for intelligent systems.
In our group, we are trying to connect new methods for artificial intelligence and to connect it with the world of robotics. And the coolest thing is that we have a whole floor of robots.
I don’t have a particular plan right now. Luckily we live in the days where there are amazing opportunities for computer scientists so I will just wait and see where they take me.
I got my master’s degree in Prague in mathematical analysis and here at IST, I got my PhD in theoretical computer science.
IST played a massive role for my career. I am really happy to say that the opportunities that I have right now are nothing I was imagining three or five years ago and if you told me I would not have believed it.
One, learn as much as you can about as much as you can. I think that IST is a great place for learning no matter which position you are holding here.
Two, be compassionate the academic environment can be very pressurizing and stressful and the sources of stress can be often different for different people so it is hard to relate. Care for the wellbeing of your coworkers and they will do the same for you.
Three, do it for the joy. I think that joy is the best motivation to do science or to do anything really.
I have had so many great memories. I had a great time in our office and playing football great time at retreats. But if I were to pick one it was the few boxing matches I had in the lecture hall.
MY RESEARCH LIES AT THE INTERFACE OF COMPUTER AND BIOMEDICAL SCIENCES AND FOCUSES ON THE STOCHASTIC PROCESSES UNDERLYING EVOLUTION. I DEVELOP COMPUTATIONAL METHODS TO LEARN FROM LARGE-SCALE BIOLOGICAL DATA SETS AND BUILD MATHEMATICAL MODELS TO EXPLAIN OBSERVATIONS ON A MECHANISTIC FASHION.
MOST RECENTLY, I FOCUSED ON INFERRING THE EVOLUTION AND THE SEEDING OF METASTASES IN PANCREATIC CANCERS.
Johannes Reiter returned to campus in Fall 2018 to give a special Think and Drink and to share his research with the current campus community. He also found time to do a video interview with us.
I don’t really have a business card but if I had one it would say Johannes Reiter instructor at the Canary Center for Cancer Early Detection at Stanford University School of Medicine.
The coolest thing is that I can work on a globally really important disease. I work on tumors and specifically tumor evolution. I try to approach this problem from a mathematical perspective I try to come up with a quantitative framework that can describe the evolution of cancer.
In the future, I still want to be at the interface of multiple fields like computer science, biology and medicine. I also want to do research in academia perhaps also together at a medical school or a hospital and work together with various researchers from these various disciplines.
My background is in computer science, originally I actually did computer engineering. Then I did computer science at the Technical University in Vienna. When I came to IST I wanted to stay in computer science but I kind of got into theoretical biology and towards the end, I got more into cancer evolution and combining data analysis and mathematical modeling.
IST played a really important role in my career because before I started here I saw myself as an engineer and not as much as a scientist. But then when I started my PhD here I got introduced into so many different areas and I got interested in areas outside of computer science and outside of computer engineering. And that is also the most interesting thing about my job currently. That I can work with experts from various different fields and that keeps my job interesting.
My advice would be: think critically and deeply, try to become independent and ask your own questions, very early on in your career. And perhaps do an internship in industry so you have a good comparison between research that is happening in academia and research that is happening outside of academia.
My favorite memory of IST are definitely all the table soccer games which we played for a lot of time basically every day after lunch.
Johannes Reiter was a PhD student in the Chatterjee group at IST Austria, and is currently doing a postdoc in Prof. Martin Nowak’s group at the Program for Evolutionary Dynamics at Harvard University.
Hania Koever, Head of the Graduate School Office, interviewed Johannes in Harvard to find out about the journey that took him there.
I followed it in the news when IST Austria was opened, the first time was when they announced an IST Lecture with Martin Nowak. I found out more about IST Austria and at the end of 2009 I decided to apply for IST and do science there.
In his IST Lecture, Martin Nowak talked about game theory and in particular the prisoner’s dilemma; it’s a simple game where you can either cooperate or defect, and he could explain so many things in evolution just with that easy game.
I studied Computer Science and just started with my master’s degree, and so I thought, that’s an advantage, you don’t even need a master’s degree—you can directly apply in the first year—this is my big chance. I came for interviews and was already very happy that I was invited.
A bit more than 10.
My project started a bit earlier, but I officially started in September 2010.
I knew it from before, because I visited for the interviews, and I went to the Open Campus Day, so I knew some people there already. I knew my likely supervisor and also some other professors from the interviews.
I still remember my first day: I didn’t really know what to expect from being in this new professional science environment. So I wasn’t sure how I should dress, for example. Then I met Krish on the first day, and I think he was running around in flip-flops as usual, so I thought, ok, maybe I shouldn’t have worried about that.[Laughs]
All these things were there already, from the beginning, so I did rotations with Krishnendu Chatterjee, Tom Henzinger and Nick Barton. There were not many professors there yet. There were maybe 7 professors, and some of them had brought their own students, so there were 11 students. Very good faculty-to-student ratio.[Laughs]
When I joined I thought I would also work on Game Theory, inspired by this lecture given by Martin Nowak. Then I worked a little bit with Tom’s wife, Monika Henzinger, at the University of Vienna. She was working on algorithmic game theory and I was very fascinated by that topic. Krish had a collaboration, so I went a little bit into that direction.
But before I started at IST Austria, Krish proposed some projects to me and they were in the evolutionary game theory area, and I started working on that and I liked it and, then had some first results and it turned out that this was a collaboration with Martin—I didn’t know that! It made me kind of happy because that was how I got interested in IST Austria in the first place, and I could even work on this project. That was the coolest. We were in touch with Martin more often, and then he[Martin Nowak]suggested to me at some point, “I need someone in computer science to work on this particular project in cancer”. He then introduced me to another area that led me on this route.
At the beginning of the PhD, not that much, because the problem is typically formalized by the supervisor already. So this is what Krish and Martin did for me. Then, the more senior you get, the more you identify problems, and you read more, and of course, you have to learn a lot of biology so that you can identify relevant problems to have an impact.
I very much liked—from the beginning—the interdisciplinary system at IST Austria. I also enjoyed the fact that in my first and second year I could take courses from different areas. That helped me a lot. Of the 7 people starting in that year, they were all in different areas. There were no two students in the same research group. And that was already in itself very cool, because when I was at TU Wien it was very different—I started with 700 students, not 7, and all of them were in computer science. Just a very different environment.
I think most of the time it was an advantage, because not many things were established, so you establish your own rules, and you just needed to convince some people that it was a good idea.
As for challenges? Of course if you want to be interdisciplinary then you have to go more outside of your comfort zone. It’s more time-consuming than just staying in your area and continuing what you have done for the last 5 years. But it’s also much more interesting.
I mean in the early days I just knew every face and, if someone joined, then I’d be “Hmm, I’ve never seen that face”, and then we’d talk. Then we grew to 30 people, 50, 100, and you lose track of all the people. Now if I go back it’s more like, “huh, I’ve never seen most people before”. But that is how it is now. I think the culture is still very similar in many ways. On the bridge[common room area linking the Central Building and the Bertalanffy Building]people from different disciplines meet—they succeeded in keeping that kind of culture.
It’s about 30km by car from IST Austria. In my hometown, almost everybody knows about IST, which is probably very different from the rest of Lower Austria where many people still don’t know about it. Also, many Austrian students here in Boston, you would think, should know about universities in Austria, but that’s not the case.
In my hometown, I know many people and many people know me. They know I was at IST Austria for some time, so they got to know that there is some great science going on there.
You actually hear about the institute very frequently, on TV, or if you read the newspaper. People don’t realize however, that IST Austria is in Klosterneuburg, or in Gugging. But slowly they are realizing, this is that outstanding institution and there’s a lot of amazing science going on.
The most challenging project we only finished basically now[two years later], and I started it in my third year of PhD, so that took a long time.
Yes, for that I had to learn a lot of new stuff, because typically I just do the theoretical analysis, mathematical modelling etc., and for this particular project we had to analyze a lot of data and in particular DNA sequencing data. So, I had to read up a lot on the literature and made a lot of mistakes along the way, starting with very naïve approaches in the beginning. But I gained more experience over the course of multiple years, and it has essentially become my main topic of research by now.
That was a rather easy decision for me, because I visited Martin frequently during my PhD so I already knew the environment here very well. And I knew it was kind of similar to IST Austria in that you have a lot of freedom to work on the problems that you’re interested in. I also knew many good people working in different areas, and of course it’s an advantage if you already started in that area and have interesting ongoing projects.
Essentially, I work on the evolution of cancer, and there are many different paths it can take—from the initiation of cancer, how it progresses, and then metastasis. So there’s a very long process which can take multiple decades from initiation to metastasis, and we basically want to understand which genetic events take place in that time to understand the evolutionary dynamics.
In particular, in the last couple of years I focused on the evolution of metastasis itself, so how it spreads from the primary tumor, which genetic precursors are needed for metastasis, where it travels to, and how long it takes.
Now that sequencing of the genome has become so cheap, a lot of science groups generate a big amount of data. It is very hard for someone who has training in biology to analyze all this data in a sophisticated way—a computer scientist or people who have training in that area can be very useful for that. What we do here in addition to analyzing these data is we try to find patterns and then make mathematical models to try to understand the underlying mechanisms—what would lead to metastasis, for example.
We work with many physician scientists who got their degree as a medical doctor and then transitioned into science and did another PhD. We collaborate with many people at Johns Hopkins for example. We also work with leading cancer physicians at an oncology lab in New York. They have access to cancer patients and can perform autopsies to obtain cancerous tissue samples found around the body and sequence all these different tissue samples. You can learn a lot about the genetic mutations present in these different metastases, and reconstruct the evolutionary history and build a picture of how the metastases might have evolved over multiple decades.
Certainly. Sometimes when you discuss a specific problem, probably our collaborator might think “oh this guy doesn’t understand even basic biology”, and then when we explain our mathematical models we think “they haven’t understood anything of what we did in the last year”. It takes a long time, but over the course of collaborations you get to learn more and more about the methods that other people use, and I find that extremely interesting.
I think the basics of doing mathematical models, understanding evolutionary dynamics, and the basic principles are similar across many field. If you are interested in the evolution of organisms and evolution of different diseases, how you would study them in a theoretical fashion is in fact very similar. One of the papers we produced during my PhD was combination therapy for cancer—how you combine different drugs. Then Martin said, that’s exactly what we did 10 or 15 years ago, in viruses, in particular, for HIV. They couldn’t treat it for a long time successfully, and then they started combining different drugs and that also came out of these mathematical models and it suddenly worked out. For cancer we could basically use these insights that he got from viruses and translated those to cancer.
That’s a very difficult question. Of course I very much enjoy what I’m doing, so I would like to stay in academia. I also benefited very much from the environment to which I was exposed at IST Austria with so many excellent people and now also at Harvard—there is this whole network of researchers. Essentially, you get to know many good people and they again know many good people, so I hope to end up at some institute where I can continue to benefit from an excellent interdisciplinary environment and I hope it will bring me to the next big thing.
But as you know the job market in academia is extremely tough, so it’s very hard to predict where you will actually land. If my job will be in Europe or central Europe, that would be amazing; if it’s somewhere else, we’ll see.
Work on the problems that you are most passionate about. I think it’s very important to not just solve a problem given to you—of course, it helps to read up on a particular area to understand what the science is about—but very early on start working on your own ideas. And learn from your mistakes—and often, setbacks. Don’t be afraid to ask other people for advice. I think from these you learn the most.
Inma Sanchez Romero was a Postdoc at IST Austria. She now works for the research Services of the University of Vienna, as an Assistant Project Manager of the INDICAR (Inter Disciplinary Cancer Research) Postdoctoral Fellowship Programme of the University of Vienna and the Technology Transfer Office. At IST Austria Inma Sanchez Romero was in Harald Janovjak’s group.
In an interview with Daniela Klammer and Kathrin Pauser which took place during the Science and Industry Day 2017 she answered some interesting questions about her work and her decision to switch from a scientific career to supporting science in a different way.
I work in research project management at the University of Vienna. Specifically, I work for a postdoctoral fellowship program called INDICAR (INterDIsciplinary CAncer Research), which is co-funded by the EU Framework Programme 7 (FP7) Marie Curie Actions.
So, on my business card it’s written my name, Ing. Inmaculada Sanchez Romero, PhD, and my position, INDICAR Assistant project manager.
My job is to support the INDICAR program and its fellows by looking for funding opportunities, writing and submitting proposals, and organizing outreach activities to disseminate information about our program and our fellows’ research. For example, I organize workshops to develop and strengthen our fellows’ skills.
There are two things that I really like about my job. One of them is organizing workshops and scientific events. And the second is that I like to think that I can have a positive impact on our fellows’ careers by looking for funding opportunities for them or by contributing to their professional development, by organizing workshops and outreach activities.
I think there are only a few positions in research project management. Once the transition is made, your professional profile becomes very specific. That might be a problem when looking for a position in another country or at another company.
I see myself working in research project management in an academic environment managing a research program and supporting its fellows.
I studied chemical engineering at the University of Granada in Spain, where I also did my masters in biotechnology. Then I obtained my PHD in chemistry working on protein engineering at the University of Granada in collaboration with Columbia University in New York, where I had three short-term research visits, and the Danish biotech company Novozymes Then later I did my postdoc at IST Austria working in synthetic biology in the Janovjak lab.
Besides all the support in scientific research at IST, I had the opportunity to collaborate and plan and organize scientific events. As a result, I explored and developed my organizational and management skills. That made me realize that I wanted to focus my career in that direction.
Work on your career development to obtain a good-sized set of transferable skills, not only by participating in workshops, but also by getting experience through volunteering, for example by organizing scientific events. Here at IST Austria there are a lot of opportunities for that.
The second one is to network, to attend conferences and workshops, to talk to people and create a solid network of contacts.
The third one is for people who are considering leaving academia. I would like them to know that they shouldn’t be afraid of the unknown. That leaving academia doesn’t mean that they have failed. It just means that they have other interests. It takes a lot of courage to follow your dreams and leave your comfort zone and to be willing to explore other possibilities.
One of my favorite moments at IST Austria was at the Young Scientists’ Symposium. I was part of the organizing committee. After all the work and all the effort organizing, it was amazing to see that it was something real. That it was happening and everything was working perfectly. The speakers and the attendees were really satisfied with the event. It was a rewarding moment and an amazing experience.
Harold De Vladar was at IST Austria from 2009 to 2013 as a postdoc in the Barton Group. He is now CEO and founder of Ribbon Biolabs GmbH. In an interview with Daniela Klammer and Kathrin Pauser which took place during the Science and Industry Day 2017 he talks about what he likes about his research but also about his career and about his time at IST Austria when IST Austria was still very small.
Harold de Vladar, my position: CEO and the name of my startup which is Ribbon Biolabs GmbH.
The essence of my job is to develop the technology to secure the IP of the technology and also to consolidate and make sure that the team is on a good track to develop the technology.
The limitations is that once you start with your own startup you have less freedom to do other things and when you come from an academic background you are probably excited about so many things and then you find yourself restricted doing stuff that you didn’t want to do in the first place like financial sheets or business plans. Which you have to do but what you want to do is just do experiments and equations’ stuff. The cool thing is that you are working for something that is entirely yours. It’s not like working for an institute for two years and after the two years that’s it. It is money you get and you construct your own stuff so it is yours. You develop it as you want you do exactly what you want it is your decision what you are doing and that rocks.
I want to develop this company obviously and I want to be in a position where I am developing new ideas new products or solving new problems related to science. So tech transfer if you wish but real problems and I want to do things that are a bit non canonical, not the standard things. I know it sounds a bit abstract but biology is very vast. There are many interesting things there that you can actually take and make a product out of it for a specific purpose. This is the things I like to make. I would also like to keep a bit of research going like basic research or more explorative research in order to allow the serendipity factor to come to new possibilities.
It’s a complex one. I started as a cell biologist and statistical physics at the same time. Then went into applied math’s only to get more formal tools to work with my stuff related to genetics and evolution. Then I did my PhD in evolutionary ecology, actually I did my PhD in evolution in a group of evolutionary ecology which is what let me to Nick Barton and that is how I ended up at IST Austria. And I also have a degree in art and science which sounds very disconnected to all this but it is not.
First of all the connectivity how I connected to the people here which are now in different places either because they were postdocs or because they were exprofessors from here in some other places this allowed a lot of connections directly or indirectly. That was something very important.
And what was also crucial. Having worked with someone like Nick Barton this was an amazing endorsement. We did great job Nick and I, what we did was awesome. It was not on the side of being extra productive but more on the side of taking very challenging problems and solving them. So it was not like salami slicing papers and that created a very idiosyncratic way of seeing science for me because I always gave more importance to this aspect than to publish many papers something that many universities don’t like.
So IST Austria determined my career in these two ways in the way I see it but also which options do I have but not by restricting them but by me realizing what is it what I want to do. I always felt more comfortable in Institutes of advanced studies small places where you can think of new things rather than the big shot universities where people go mad with the latest nature cover and you have to race with them. That’s not my style.
For the postdocs of IST Austria: Things have probably changed a lot since I left IST Austria but I think there are two levels of things that you have to learn as a postdoc. First of all you have to do your work project as it means of learning maturing etc. but you also have to keep a close eye on what you want and what are the next career steps. You can get very distracted with your project and forget that there is a future that you have to fulfill. And I saw many postdocs forgetting these things.
Second, I feel like there is a lot of gab between what is a postdoc and what is a professor and IST doesn’t give this feeling of continuity between one and the other. I think at least in my time it was great to be here as a first postdoc but not as a second because you won’t have that much independence you won’t have that much support beyond your project.
I think it was one of these barbeques and we went into the pond, swimming in the pond. I don’t think Tom Henzinger was so happy with us the next day. This was when IST was relatively small. We could have staff meetings of the whole institute every week and these meetings didn’t get to more than 20 people. None of the building existed. That was very fun.
Very simple what kind of problems do I really want to solve and how.
Stefan Huber was at IST Austria from 2013 to 2015 as a postdoc in the Edelsbrunner Group. He is now a researcher at Bernecker + Rainer in industrial R&D. In his interview, he talks about his research but also about his career and about his time at IST Austria.
Stefan Huber, Research and Development
I designed the software concept that means the algorithms, the mathematical models for the next generation industrial transport system of B&R which is called ACOBOStrak.
The coolest thing I think is: It is a very interdisciplinary project. There are bright people from control theory, from mathematics, computer science and together we shape a new kind of technology that could actually change the way industrial machines are built in the future.
I believe that the current R&D project I am working on kind of demonstrates how computer science has a deep impact on industrial automatization. I think this is only a start so in the future I would like to shape a stronger group in the company that focuses on computer science algorithms and mathematics.
My academic background is actually algorithms more precisely it is computational geometry and topology so I have a double degree in computer science and mathematics. I studied in Salzburg I did my PhD in computational geometry and then for a short time I was a senior scientist at the math department. After that I joined Herbert Edelsbrunner’s group at IST Austria for two years in computational topology.
To me IST Austria was intellectually very inspiring. So looking back at IST I see that the experiences that I gained at IST gave me a lot of confidence and trust in scientific principles and that again has an influence in my work because I know that I can trust on scientific methodologies to solve the problems I face in my industry job.
First actively participate in intellectual exchanges.
Try to go to as many workshops and conferences as you can do.
And third use the freedom and opportunities you get from IST Austria. In my case I wasn’t forced to pursue a particular direction in my research. So that’s a nice thing you are completely open. They are very generous when it comes to visiting conferences and there are a lot of scientific visitors to get in touch and to have discussions after a talk when drinking a glass of wine or going to Heurigen.
What I really loved was when there were big visitors like Steve Smale and we went to Heurigen for dinner in the evening and the kind of talks that developed at an evening event are quite different and I enjoyed that very much.
Vicent Botella-Soler was a Postdoc at IST Austria. He now works for ForwardKeys in Spain. ForwardKeys analyses global travel movements to help companies improve their tactical decision making. At IST Austria Vicent Botella-Soler was a Postdoc in Gašper Tkačik’s group.
In an interview with Daniela Klammer and Kathrin Pauser which took place during the Science and Industry Day 2017 he answered some interesting questions about his work.
Vicent Botella-Soler, Innovation and Machine Learning Manager at ForwardKeys
At ForwardKeys we analyze large datasets from the travel industry to provide forecasts and insights to our clients. We maintain a daily-updated database of all the flight bookings worldwide. The analysis of this large amount of data allows us to answer interesting questions in industry sectors such as retail, hospitality, tourism management or financial services.
It is very nice to have a sort of magnifying glass above the planet and watch, almost in real-time, how people move around and how different events and contexts affect the flow.
Limitations are all the typical limitations intrinsic to working with data…there are plenty of them, but these are the daily challenges you’ve got to get used to.
I see myself working on this kind of quantitative, analytic, data-driven problems. Also, I’ll make sure that I keep learning new skills and new techniques—that is what I find most exciting.
I studied theoretical physics and did a master in astrophysics. For my PhD I moved to dynamical systems and neuroscience. Here at IST Austria I worked in computational science, applying machine learning techniques to the problem of decoding visual stimuli from the spiking response of the retinal neurons.
Both through my work and by meeting and being in touch with very good scientists, I think I gained the skills and the confidence to be where I am now.
First and foremost, don’t put all your eggs in one basket. Make sure you give yourself plenty of possibilities and allow enough flexibility when you confront your future.
Always look around, talk to people in different fields and in industry, and also in different career paths. This way you can get a good idea of the context in which your career moves.
Also, it is very important that you trust your skills. Trust that the knowledge and habits that you have gained in science are valuable beyond the walls of academia.
When I came to IST it was still fairly small. It was very nice to go around campus during the first weeks and find that everybody just introduced themselves to you. It was easy to identify the newcomers and make them feel welcome.
And of course I met my wife here and my two kids where born while I was working at IST, so I keep many fond memories attached to the Institute.
It was mostly a family choice. We wanted to have a say in where we lived. So we chose where we wanted to live, and then our careers had to adapt to our decision.
MY RESEARCH AREA RELATES TO USING PROGRAMMING LANGUAGES AND FORMAL METHODS TO HELP PROGRAMMERS AND DESIGNERS DEVELOP RELIABLE, SAFE, AND CORRECT SYSTEMS. IN PARTICULAR, I HAVE BEEN WORKING HEAVILY ON PROGRAM SYNTHESIS. HOWEVER, I’M INTERESTED IN ALL DOMAINS OF FORMAL METHODS AND RIGOUROUS SYSTEM ENGINEERING.
Arjun Radhakrishna joined IST Austria in 2009 as a PhD student in Thomas A. Henzinger’s group. His doctoral thesis on “Quantitative Specifications for Verification and Synthesis” won the ACM SIGBED Paul Caspi Memorial Dissertation Award. Currently, Arjun is a postdoctoral researcher at the University of Pennsylvania. We interviewed Arjun about his experience as a PhD student and about his transition to postdoctoral researcher.
I first became interested in computer science in high school when I learnt about programming. This was about 15 years ago, so the interest has always been there and has stayed with me.
I did my PhD right after my bachelor’s. After my bachelor’s I still felt that there were more things to learn than I already knew. I had the opportunity, so I decided to take it.
That was mainly because of Tom [Henzinger]. I did an internship with him when he was still at EPFL. I really liked the work I did during the internship and asked if I could work with him. He replied that he was moving to IST Austria so I decided to join him there.
It was really nice. We had a very pleasant group of people to work with. Something you come to appreciate is that the group you work with is just as important as the advice you get on your work. Tom is really good—there is no question about that. That is by the way another great thing about IST Austria, that the faculty is really good. We had advice available for whatever project we were working on.
We met about once a week on average. Meeting Tom once a week was really a privilege. Within a few minutes, he could understand exactly what I had been doing the previous week and could give me thoughts and advice that would guide me for the next week. He has this skill that many good researchers have of asking exactly the right questions that makes you think about the problem in the right way.
I also did a lot of work together with postdocs and we had a lot of fruitful collaboration together.
Paint, and I read a lot. Reading was my main hobby. My new year’s resolution every year while I was a PhD student was to read one novel a week. [Laughs] I never quite achieved that, but I read a lot. Two of my favorite authors are Milan Kundera and Terry Pratchett.
As a graduate student you’re mainly working on your research. But at IST Austria you also develop a way of thinking, which is much broader than what you get at a regular computer science or engineering department.
The great thing about being at IST Austria is that you get to meet people from a wide range of subject areas, such as computer science, life sciences, and mathematics. This broadens your mind.
At UPenn, I am at the school of engineering and applied science. I get to meet a lot of people who are doing cool engineering, and I didn’t have that chance before. That’s something different. There are also more students at UPenn than at IST Austria and this also gives me more opportunities to teach.
It’s definitely not smooth sailing. You struggle a bit, you have your ups and downs. But that’s what the PhD is about. You stay with it, and you persevere.
It’s really hard to give advice. Every student is different and every advisor is different. But I would say, perhaps try not to stick to just one problem but work on a few different problems. And as I suggested before, for a PhD student, much more important than any other quality is perseverance.
PRECLINICAL DRUG DISCOVERY IN NEUROSCIENCE WITH FOCUS ON ELECTROPHYSIOLOGY, OPTOGENETICS, AND DATA ANALYSIS
Philipp Schönenberger was a postdoc in the Csicsvári group from 2011 to 2015 before moving to his current position in industry. He is now a research scientist at Roche, a multinational healthcare company. He works in preclinical drug discovery in neuroscience with focus on electrophysiology, optogenetics, and data analysis.
During a visit to IST Austria in June 2017, he talked to Daniela Klammer and Kathrin Pauser about what it is like to be a researcher in industry, how he perceives the transition from academia to industry, and how to be successful in the job application process.
Also while on campus, he gave current students helpful tips on how to successfully apply to industry jobs during a special Think&Drink.
This is simple: “scientist”.
The coolest thing about my job is that we provide data that informs decisions about how to move ahead with projects. I like publications, but they can be the end of a story: everybody is happy, and you move on to the next thing. In our case, however, if we have data that is useful, it will be used later by other teams. This is very satisfying.
Somewhere around science, I think. I am a scientist at my heart, and now, I have seen more and more functions around science that are extremely interesting. So, while I don’t think I want to do experiments for the rest of my life, I want to be close to science. I particularly like this place between the preclinical and clinical development phases because it represents a major challenge in drug discovery. It’s a high risk transition, and if I can contribute to bridging that gap, then this is an enormous achievement as well as an interesting challenge.
I have a master’s in cell biology; in particular, I studied viral infections and the transport of viruses. Later, I moved into in vitro neuroscience in order to understand how neurons exchange signals. Then, it was a natural step to ask the same questions, but this time for the “intact” animal—in particular, to understand how neuron communication contributes to the formation of memories. That is essentially why I came to IST and chose to work with Jozsef.
It is here that I learned the concepts behind this kind of research, and gained the expertise necessary to perform it. It was absolutely fun, and also prerequisite for my current function. Plus, scientifically speaking, this kind of research is the most interesting thing you can do. My world view is still influenced by these experiences.
I encourage everybody to go to job fairs. I thought I was always too busy for that, and I don’t like networking. But I would still encourage everyone to do this. Even if you find out that something is not your cup of tea, then at least you know.
I think the difficult thing is the transition from academia to a place you don’t know. Industry was a big unknown—at least it was for me—but I now realize it was the same for most of my colleagues. Talking to people and networking helps a lot. That’s one thing I would definitely encourage.
And then, it’s not a bad idea to build up your CV a bit. Things like mentoring experience don’t hurt, a one- or two-day project management course can be helpful, too. All these things that you hear about, but usually ignore. When a company gets applications, they have a few things they want to see. It is so much easier when they know somebody has been exposed to industry, so they know the applicant knows roughly how it works and is interested. Your CV is what they use to make that first decision.
Internships help, I did one. Back then I was not specifically interested in disease, but during my master’s I did an internship in Cardiff in a group that works on Huntington’s disease. Of course I wrote that in bold letters on my cover letter. Why? Because a company looks for someone with not only the skills, but also the interest. Somebody who understands the questions behind the research. In a cover letter or CV, an internship is like a label: “I tried it, I liked it”. If you have a chance to do an industry internship, it is very valuable: it can be a door opener…and it can also make you certain that you don’t want to go into industry!
One specific event I remember is when—after a year and a half of work—my experiment worked for the first time. That is something I will always remember, first because it was really hard, and second because all these people said: “This can’t work, the physics almost forbids this.” This was a scientific “eureka” moment.
And then, I have many fond memories of sitting at the IST pond with my colleges and taking lots of time to discuss ideas in depth. I don’t have time for this now, and this is what I miss.
The diverse options—in the longer run—that you have in a company. For me, that was the most important factor.
Very simple! There are only a handful of labs in Europe that do this type of research, and Jozsef’s was one of them. He told me from the beginning that he was moving to IST, and I thought living in Vienna must be fantastic…I loved living in Klosterneuburg, it was a pleasure to be able to cycle to work and still be only 20 minutes from the city.
I saw the job and thought it sounded very interesting, and that it would be an excellent opportunity. Then, I contacted someone I know who worked at Roche, to get an idea of what they are looking for in an applicant. Later, they contacted me for a phone interview.
Practice a lot, and even rehearse for a possible video interview. While preparing, check things like the background, and make sure there would be good light, but for instance no window behind you.
Also come up with some questions beforehand. Don’t be passive! It’s good to show interest, and not only that, it is your chance to find out if this is the right job for you.
Research in academia and research in industry are both science on a high level, but in industry, research is far more cooperative. We have to work together: it is not only the group that has to succeed, it is the entire section.