Jun 4, 2019
Understanding Ras Sensitivity to Mutation by High-Throughput Mutagenesis
Date: June 4, 2019 |
2:00 pm –
3:30 pm
Speaker:
John Kuriyan, Howard Hughes Medical Institute Departments of Molecular & Cell Biology and Department of Chemistry, UC Berkely
Location: Big Seminar room Ground floor / Office Bldg West (I21.EG.101)
Ras and many other proteins that are oncogenic, i.e., associated with cancer when mutated, are allosteric switches. The growing power of gene synthesis and next-generation sequencing can be harnessed to yield insights into molecular mechanism in a novel way. I will cover the application of high-throughput mutagenesis to Ras, combined with structural analysis and molecular dynamics simulations, with an emphasis on understanding the allosteric mechanisms that lead to mutational sensitivity.
