Kondrashov Group

Evolutionary Genomics

How did living organisms become the way we know them today? The Kondrashov lab is focused on understanding the natural world in an evolutionary context, typically focusing on studying genetic information due the abundance of DNA and protein sequence data.

Kondrashov and his group do not restrict themselves to studying specific functions or phenotypes, instead, a staple feature of their research is a focus on how functions and phenotypes change over time. Therefore, their research is inherently interdisciplinary, grounded in classical evolutionary fields of population genetics and molecular evolution while drawing from other fields, such as cell and molecular biology, bioinformatics, and biophysics. Recently, the group has become increasingly interested in the experimental assay of fitness landscapes. Combining experiments, theory, and computational biology, they query how changes in the genotype affect fitness or specific phenotypes. In the near future, they hope to expand their experimental capabilities in order to query a wider range of interesting phenotypes in a high-throughput manner.

Group Leader


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Team

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Olga Bochkareva

Postdoc

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Louisa Gonzalez Somermeyer

PhD Student

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Mia Juracic

Project Technician


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Anastasia Lyulina

Laboratory Technician

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Nick Machnik

PhD Student

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Ekaterina Maksimova

Project Technician


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Aygul Minnegalieva

Project Technician

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Rodrigo Redondo

Project Technician

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Stefan Riegler

PhD Student


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Catalin Rusnac

PhD Student

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Anastasia Stolyarova

Predoctoral Visiting Scientist

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Petr Vlasov

Postdoc


Current Projects

Empirical fitness landscapes | Protein evolution in the context of epistasis | Population genomics of the spoon-billed sandpiper


Publications

Uroshlev LA, Abdullaev ET, Umarova IR, Il’Icheva IA, Panchenko LA, Polozov RV, Kondrashov F, Nechipurenko YD, Grokhovsky SL. 2020. A method for identification of the methylation level of CpG islands from NGS data. Scientific Reports. 10, 8635. View

Mitiouchkina T, Mishin AS, Gonzalez Somermeyer L, Markina NM, Chepurnyh TV, Guglya EB, Karataeva TA, Palkina KA, Shakhova ES, Fakhranurova LI, Chekova SV, Tsarkova AS, Golubev YV, Negrebetsky VV, Dolgushin SA, Shalaev PV, Shlykov D, Melnik OA, Shipunova VO, Deyev SM, Bubyrev AI, Pushin AS, Choob VV, Dolgov SV, Kondrashov FA, Yampolsky IV, Sarkisyan KS. 2020. Plants with genetically encoded autoluminescence. Nature Biotechnology. View

Garriga E, Di Tommaso P, Magis C, Erb I, Mansouri L, Baltzis A, Laayouni H, Kondrashov F, Floden E, Notredame C. 2019. Large multiple sequence alignments with a root-to-leaf regressive method. Nature Biotechnology. 37(12), 1466–1470. View

Sigalova OM, Chaplin AV, Bochkareva O, Shelyakin PV, Filaretov VA, Akkuratov EE, Burskaia V, Gelfand MS. 2019. Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. BMC Genomics. 20(1), 710. View

Noda-García L, Davidi D, Korenblum E, Elazar A, Putintseva E, Aharoni A, Tawfik DS. 2019. Chance and pleiotropy dominate genetic diversity in complex bacterial environments. Nature Microbiology. 4(7), 1221–1230. View

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Career

since 2017 Professor, IST Austria
since 2012 Scientific Director of the School of Molecular and Theoretical Biology
2011 – 2017 ICREA Research Professor, Centre for Genomic Regulation, Barcelona, Spain
2008 – 2017 Junior Group Leader, Centre for Genomic Regulation, Barcelona, Spain
2008 PhD, University of California, San Diego, USA


Selected Distinctions

2017 ERC Consolidator Grant
2016 Plan Estatal, Spanish Ministry of Economics and Competitiveness
2016 Zimin Foundation Grant for School of Molecular and Theoretical Biology
2014 ERC Starting Grant
2013 Plan Nacional Grant, Spanish Ministry of Economics and Competitiveness
2012 Howard Hughes Medical Institute International Early Career Scientist Award
2011 EMBO Young Investigator Award
2010 Theodosius Dobzhansky Prize from Society for the Study of Evolution
2010 Plan Nacional Grant, Spanish Ministry of Science and Innovation
2005 National Science Foundation Graduate Research Fellow


Additional Information

Download CV

ERC Consolidator Grant website



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