Evolutionary Genomics

How did living organisms become the way we know them today? This is the fundamental question that our laboratory is preoccupied with. We are less concerned with understanding the organisms themselves, our main focus is on how they evolved, that is how they changed over time. To address these fundamental issues we employ a diversity of modern tools. We apply mathematical modeling, we use available bioinformatic data and we perform our own experiments with a diversity of different model and non-model organisms. So far, our main focus has been the elucidation of the impact of genetic interactions on molecular evolution. We have been studying how often and in what manner one genetic change affects the impact of another, mostly within the context of one amino acid change affecting other amino acid changes in the same protein. We believe that genetic interactions may be more common than previously accepted, and such interactions may play an important part in determining the rate of change of amino acid sequences. Members of the lab are free to choose their own direction of research, accepting the responsibility for the direction of research alongside that freedom. Inquiries from potential students and postdocs are welcome.

Contact
Fyodor Kondrashov
Institute of Science and Technology Austria (IST Austria)
Am Campus 1
A – 3400 Klosterneuburg
E-mail: fkondrashov@remove-this.gmail.com

»CV and Publication List

Assistant
Alexandra Mally

Phone: +43 (0)2243 9000-1105
E-mail: alexandra.mally@remove-this.ist.ac.at

Selected Publications

  • Sarkisyan KS, Bolotin DA, Meer MV, Usmanova DR, Mishin AS, Sharonov GC, Ivankov DN, Bozhanov NG, Baranov MS, Soylemez O, Bogatyreva NS, Vlasov PK, Egorov ES, Logacheva MD, Kondrashov AS, Chudakov DM, Putintseva EV, Mamedov IZ, Tawfik DS, Lukyanov KA, Kondrashov FA. (2016) Local fitness landscape of the green fluorescent protein. Nature. 533, 397-401.
  • Arkhipova OV, Meer MV, Mikoulinskaia GV, Zakharova MV, Galushko AS, Akimenko VK, Kondrashov FA. (2015) Recent Origin of the Methacrylate Redox System in Geobacter sulfurreducens AM-1 through Horizontal Gene Transfer. PLoS One. 10, e0125888
  • Usmanova DR, Ferretti L, Povolotskaya IS, Vlasov PK, Kondrashov FA. (2015) A model of substitution trajectories in sequence space and long-term protein evolution. Mol Biol Evol. 32, 542-554.
  • Moroz LL, Kocot KM, Citarella MR, Dosung S, Norekian TP, Povolotskaya IS, Grigorenko AP, Dailey C, Berezikov E, Buckley KM, Ptitsyn A, Reshetov D, Mukherjee K, Moroz TP, Bobkova Y, Yu F, Kapitonov VV, Jurka J, Bobkov YV, Swore JJ, Girardo DO, Fodor A, Gusev F, Sanford R, Bruders R, Kittler E, Mills CE, Rast JP, Derelle R, Solovyev VV, Kondrashov FA, Swalla BJ, Sweedler JV, Rogaev EI, Halanych KM, Kohn AB. (2014) The ctenophore genome and the evolutionary origins of neural systems. Nature. 510, 109-114.
  • Koval AV, Vlasov P, Shichkova P, Khunderyakova S, Markov Y, Panchenko J, Volodina A, Kondrashov FA, Katanaev VL. (2014) Anti-Leprosy Drug Clofazimine Inhibits Growth of Triple-Negative Breast Cancer Cells via Inhibition of Canonical Wnt Signaling. Biochem Pharmacol. 87, 571-578.
  • Arkhipov V.Yu. Noah, N., Koschkar, S., Kondrashov, F.A. (2013) Birds of Mys Shmidta, north Chukotka, Russia. Forktail 29, 25-30.
  • Breen MS, Kemena C, Vlasov PK, Notredame C, Kondrashov FA. (2012) Epistasis as the primary factor in molecular evolution. Nature 490, 535-538.
  • Kondrashov FA (2012). Gene duplication as a mechanism of genomic adaptation to a changing environment. Proc Biol Sci. 279, 5048-5057.
  • Povolotskaya IS, Kondrashov FA (2010). Sequence space and the ongoing expansion of the protein universe. Nature. 465, 922-926.
  • Meer MV, Kondrashov AS, Artzy-Randrup Y, Kondrashov FA (2010). Compensatory evolution in mt-tRNAs navigates valleys of low fitness. Nature. 464, 279-282.

Career

Since 2017  Professor at the IST, Austria
Since 2012  Scientific Director of the School of Molecular and Theoretical Biology
2011–2017 ICREA Research Professor at the CRG, a tenure position
2008–2017 Junior Group Leader at the Center for Genomic Regulation
Since 2005  Summer field work expeditions in Siberia and the Arctic
2000–2003  Research Scientist, NCBI, NIH

Selected Distinctions

2016 Plan Estatal from Spanish Ministry of Economics and Competitiveness
2016 Zimin Foundation grant for School of Molecular and Theoretical Biology
2014–2018 ERC Starting Grant
2013–2015 Plan Nacional Grant from Spanish Ministry of Economics and Competitiveness
2012–2017 Howard Hughes Medical Institute International Early Career Scientist Award
2011–2013 EMBO Young Investigator Award
2010 Theodosius Dobzhansky Prize from Society for the Study of Evolution
2010–2012 Plan Nacional Grant from Spanish Ministry of Science and Innovation
2005–2008 National Science Foundation Graduate Research Fellow

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