Alicia Michael will join ISTA in April 2024.
Genome Regulation and Biological Timekeeping
Circadian rhythms are universal biological phenomena in various life forms, from single-cell green algae to humans. These rhythms are tightly linked to the daily light-dark cycle and synchronize physiology and behavior with the solar day. They serve as an evolutionary adaptation, allowing organisms to anticipate and adjust to daily environmental changes. In mammals, the disruption of circadian rhythms, whether caused by external influences or genetic factors, can lead to numerous diseases, including diabetes, cardiovascular issues, premature aging, and cancer. Notably, nearly every cell in the human body possesses an internal molecular clock, orchestrating integrated biochemical processes on a roughly 24-hour cycle. The molecular clockwork coordinates nuclear processes such as the three-dimensional (3D) organization of DNA, transcription, and ribosome biogenesis to achieve its extensive influence, giving rise to a daily peak in gene activity.
The Chromatin Structure and Rhythms lab aims to decipher how the spatial organization of genes and macromolecular assemblies within the nucleus contributes to precise and environmentally sensitive gene control. We are particularly interested in investigating how transcription factors and their cofactors interact with chromatin, a dynamic structure formed by DNA and histone proteins, to control gene activity. We employ diverse techniques such as biochemistry, chemical biology, and genomics to uncover how the interplay between transcription factors and the histone code – the chemical tags on chromatin – influences gene regulation. We also use cutting-edge imaging techniques like cryo-electron microscopy (cryo-EM), including single-particle and tomography approaches, to elucidate the ultrastructure of chromatin and its regulatory complexes within cells. By utilizing the circadian system as a model in diverse organisms, including human cells and green algae, we seek to unravel fundamental principles of gene regulation across multiple biological scales and gain insights into how cells keep time.
Multiple PhD student and postdoc positions are available! Prospective PhD students: please apply through https://phd.pages.ista.ac.at
Postdocs and Master/pre-doctoral students: Send your CV and a brief motivation letter to Alicia. In your letter, share why you’re interested in our lab, the research questions you are most curious about, and your vision for a good research environment.
Deciphering how transcription factors interface with the histone code | Examining the molecular coordination of the chromatin landscape at a core clock gene | Probing chromatin structure at high resolution within green algae
ReX-Link: Alicia Michael
Starting 2024 Assistant Professor, Institute of Science and Technology Austria (ISTA)
2023 – 2024 Postdoc, Biozentrum of the University of Basel, Switzerland
2017 – 2022 Postdoc, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2011 – 2017 PhD, University of California, Santa Cruz, USA
2023 Eppendorf Award for Young European Investigators, Finalist
2022 Life Sciences (LS2) Swiss PIs of Tomorrow Jury Prize
2019 Friedrich Miescher Institute Ruth Chiquet Originality Prize
2019 – 2021 HFSP Long-term fellowship
2017 – 2019 EMBO Long-term fellowship
2014 – 2017 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship