PhD Student

Am Campus 1

3400 Klosterneuburg

+43 664 88326094

Email: chong.chen@remove-this.ist.ac.at

 

Research Area

I am working on the mechanisms of synaptic transmission at GABAergic synapses formed by basket cells on Purkinje cells in the cerebellum. This synapse is located perisomatically, has a large synaptic amplitude, and therefore allows perfect experimental conditions for determining the quantitative properties of synaptic transmission. I am particularly interested in the kinetic and molecular properties of the Ca2+ sensor of exocytosis, presumably synaptotagmin 2, at these synapses. To address this question, I am currently comparing the properties of wild-type and synatotagmin 2 knockout synapses, and trying to rescue the phenotype by adenoviral infection. To measure synaptic transmission precisely, I am making paired recordings between basket cells and Purkinje cells in slices.