2015


Kiermaier E, Moussion C, Veldkamp CT, Gerardy-Schahn R, de Vries I, Williams LG, Chaffee GR, Phillips AJ, Freiberger F, Imre R, Taleski D, Payne RJ, Braun A, Förster R, Mechtler K, Mühlenhoff M, Volkman BF, Sixt M.
Polysialylation controls dendritic cell trafficking by regulating chemokine recognition.
Science. 2016 Jan 8;351(6269):186-90.


Sixt M, Raz E.
Editorial overview: Cell adhesion and migration.
Curr Opin Cell Biol. 2015 Oct.


Sarris M, Sixt M.
Review: Navigating in tissue mazes: chemoattractant interpretation in complex environments.
Curr Opin Cell Biol. 2015 Oct;36:93-102.


Kiermaier E, Sixt M.
Comment: IMMUNOLOGY.
Fragmented communication between immune cells.
Science. 2015 Sep 4;349(6252):1055-6.


Veldkamp CT, Kiermaier E, Gabel-Eissens SJ, Gillitzer ML, Lippner DR, DiSilvio FA, Mueller CJ, Wantuch PL, Chaffee GR, Famiglietti MW, Zgoba DM, Bailey AA, Bah Y, Engebretson SJ, Graupner DR, Lackner ER, LaRosa VD, Medeiros T, Olson ML, Phillips AJ, Pyles H, Richard AM, Schoeller SJ, Touzeau B, Williams LG, Sixt M, Peterson FC.
Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.
Biochemistry. 2015 Jul 14;54(27):4163-6.


Chabaud M, Heuzé ML, Bretou M, Vargas P, Maiuri P, Solanes P, Maurin M, Terriac E, Le Berre M, Lankar D, Piolot T, Adelstein RS, Zhang Y, Sixt M, Jacobelli J, Bénichou O, Voituriez R, Piel M, Lennon-Duménil AM.
Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells.
Nat Commun. 2015 Jun 25;6:7526.


Holst K, Guseva D, Schindler S, Sixt M, Braun A, Chopra H, Pabst O, Ponimaskin E.
The serotonin receptor 5-HT₇R regulates the morphology and migratory properties of dendritic cells.
J Cell Sci. 2015 Aug 1;128(15):2866-80.


Hons M, Sixt M.
Comment: The lymph node filter revealed.
Nat Immunol. 2015 Apr;16(4):338-40.


Maiuri P, Rupprecht JF, Wieser S, Ruprecht V, Bénichou O, Carpi N, Coppey M, De Beco S, Gov N, Heisenberg CP, Lage Crespo C, Lautenschlaeger F, Le Berre M, Lennon-Dumenil AM, Raab M, Thiam HR, Piel M*, Sixt M*, Voituriez R*.
Actin flows mediate a universal coupling between cell speed and cell persistence.
Cell. 2015 Apr 9;161(2):374-86. * corresponding authors


Heger K, Kober M, Rieß D, Drees C, de Vries I, Bertossi A, Roers A, Sixt M, Schmidt-Supprian M.
A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors.
Eur J Immunol. 2015 Jun;45(6):1614-20.


Ruprecht V, Wieser S, Callan-Jones A, Smutny M, Morita H, Sako K, Barone V, Ritsch-Marte M, Sixt M, Voituriez R, Heisenberg CP.
Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
Cell. 2015 Feb 12;160(4):673-85.

 

2014


Vaahtomeri K, Sixt M.
Comment: Physiology: Relax and come in.
Nature. 2014 Oct 23;514(7523):441-2.


Majumdar R, Sixt M, Parent CA.
Review: New paradigms in the establishment and maintenance of gradients during directed cell migration.
Curr Opin Cell Biol. 2014 Oct;30:33-40.


Stoler-Barak L, Moussion C, Shezen E, Hatzav M, Sixt M, Alon R.
Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects.
PLoS One. 2014 Jan 22;91.


Dueck A, Eichner A, Sixt M, Meister G.
A miR-155-dependent microRNA hierarchy in dendritic cell maturation and macrophage activation.
FEBS Lett. 2014 Feb 14;588(4):632-40.

 

2013




Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt M, Strobl H.

Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.

Eur J Immunol. 2013 Oct 28. 



Fuertbauer E, Zaujec J, Uhrin P, Raab I, Weber M, Schachner H, Bauer M, Schütz GJ, Binder BR, Sixt M, Kerjaschki D, Stockinger H.

Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells.

Immunol Lett. 2013 Jul-Aug;154(1-2):31-41.




Moussion C, Sixt M.

Comment: A conduit to amplify innate immunity.

Immunity. 2013 May 23;38(5):853-4.


Weber M, Sixt M.
Live cell imaging of chemotactic dendritic cell migration in explanted mouse ear preparations.

Methods Mol Biol, 2013;1013:215-26.




Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler DF, Luther SA, Bollenbach T, Sixt M.

Interstitial dendritic cell guidance by haptotactic chemokine gradients.

Science, 2013 Jan 18;339(6117):328-32.




 

2012


Zhang L, Orban M, Lorenz M, Barocke V, Braun D, Urtz N, Schulz C, von Brühl ML, Tirniceriu A, Gaertner F, Proia RL, Graf T, Bolz SS, Montanez E, Prinz M, Müller A, von Baumgarten L, Billich A, Sixt M, Fässler R, von Andrian UH, Junt T, Massberg S.
A.
Novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.

J Exp Med. 2012 Nov 12.




Schachtner H, Li A, Stevenson D, Calaminus SD, Thomas SG, Watson SP, Sixt M, Wedlich-Soldner R, Strathdee D, Machesky LM.

Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo.

Eur J Cell Biol. 2012 Nov;91(11-12):923-9.




Sixt M.

Comment: Cell migration: fibroblasts find a new way to get ahead.

J Cell Biol. 2012 Apr 30;197(3):347-9.




Hepper I, Schymeinsky J, Weckbach LT, Jakob S, Frommhold D, Sixt M, Laschinger M, Sperandio M, Walzog B.

The mammalian actin-binding protein 1 is critical for spreading and intraluminal crawling of neutrophils under flow conditions.

J Immunol. 2012 May 1;188(9):4590-601.

 

2011




Wendland M, Willenzon S, Kocks J, Davalos-Misslitz AC, Hammerschmidt SI, Schumann K, Kremmer E, Sixt M, Hoffmeyer A, Pabst O, Förster R.

Lymph node T cell homeostasis relies on steady state homing of dendritic cells.

Immunity. 2011 Dec 23;35(6):945-57.




Eichner A, Sixt M.

Comment: Setting the clock for recirculating lymphocytes.

Sci Signal. 2011 Nov 8;4(198):pe43.




Schraivogel D, Weinmann L, Beier D, Tabatabai G, Eichner A, Zhu JY, Anton M, Sixt M, Weller M, Beier CP, Meister G.

CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells.

EMBO J. 2011 Aug 19;30(20):4309-22.




Soriano SF, Hons M, Schumann K, Kumar V, Dennier TJ, Lyck R, Sixt M, Stein JV.

In vivo analysis of uropod function during physiological T cell trafficking.

J Immunol. 2011 Sep 1;187(5):2356-64. 



Sixt M, Lämmermann T.

In vitro analysis of chemotactic leukocyte migration in 3D environments.

Methods Mol Biol. 2011;769:149-65.




Link A, Hardie DL, Favre S, Britschgi MR, Adams DH, Sixt M, Cyster JG, Buckley CD, Luther SA.

Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans.

Am J Pathol. 2011 Apr;178(4):1662-75.




Sixt M, Parent CA.

Comment: Cells on the move in Philadelphia.

Mol Biol Cell. 2011 Mar 15;22(6):724.




Sixt M.

Review: Interstitial locomotion of leukocytes.

Immunol Lett. 2011 Jul;138(1):32-4.




Renkawitz J, Sixt M.

Review: Mechanisms of force generation and force transduction during interstitial leukocyte migration.

EMBO Rep, 2010 Oct;11(10):744-50.




 

2010




Weber M, Sixt M.

Comment: MEK signaling tunes actin treadmilling for interstitial lymphocyte migration.

EMBO Journal, 2010 Sep 1;29(17):2861-3.




Schumann K, Lämmermann T, Bruckner M, Legler DF, Polleux J, Spatz JP, Schuler G, Förster R, Lutz MB, Sorokin L, Sixt M.
Immobilized chemokine fields and soluble chemokine gradients shape migration patterns of dendritic cells.

Immunity, 2010 May 28;32(5):703-13.




Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt M, Newcombe J, Wekerle H, Hohlfeld R, Lassmann H, Meinl E.

Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells.

Brain Pathol, 2010 Sep;20(5):966-75.




Nourshargh S, Hordjik P, Sixt M.

Review: Regulation of leukocyte motility: through venular walls and beyond.

Nat Rev Mol Cell Biol, 2010 May;11(5):366-78.




Riedl J, Flynn KC, Raducanu A, Gärtner F, Beck G, Bösl M, Bradke F, Massberg S, Aszodi A, Sixt M*, Wedlich-Söldner R.*

Lifeact mice for studying F-actin dynamics.

Nat Methods, 2010 Mar;7(3):168-9.




 

2009




Pflicke H, Sixt M.
Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels.

J Exp Med, 2009 Dec 21;206(13):2925-35.




Renkawitz J, Schumann K, Weber M, Lämmermann T, Pflicke H, Polleux J, Spatz JP, Sixt M.

Adaptive force transmission in amoeboid cell migration.

Nat Cell Biol, 2009 Dec;11(12):1438-43.




Schymeinsky J, Gerstl R, Mannigel I, Niedung K, Frommhold D, Panthel K, Heesemann J, Sixt M, Quast T, Kolanus W, Mocsai A, Wienands J, Sperandio M, Walzog B.

A fundamental role of mAbp1 in neutrophils: impact on β2 integrin-mediated phagocytosis and adhesion in vivo.

Blood, 2009 Nov 5;114(19):4209-20.




Lammermann T, Sixt M.

Review: Mechanical modes of amoeboid cell migration.

Curr Opin Cell Biol, 2009 Oct;21(5):636-44.




Wolf AM, Hochegger K, Zeiser R, Duerr C, Gerlach UV, Sixt M, Markut L, Baier G, Rosenkranz AR, Wolf D.

FTY720 abrogates the therapeutic potential of adoptively transferred Treg via inhibition of IL-2 induced in vivo expansion.

J Immunol, 2009 Sep 15;183(6):3751-60.




Lämmermann T, Renkawitz J, Wu X, Brakebusch C, Sixt M.

Plenary paper: Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration.
Blood, 2009 Jun 4;113(23):5703-10.




Quast T, Tappertzhofen B, Schild C, Grell J, Czeloth N, Forster R, Alon R, Fraemohs L, Dreck K, Weber C, Lammermann T, Sixt M, Kolanus W.

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.

Blood, 2009 Jun 4;113(23):5801-10.




Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S., Sixt M, Wang HV, Sperandio M, Fässler R.

Kindlin-3 is required for β2 integrin-mediated leukocyte adhesion to endothelial cells.
Nat Med, 2009 Mar;15(3):300-5.




Bauer M, Brakebusch C, Coisne C, Sixt M, Wekerle H, Engelhardt B, Fassler R.

Beta 1 Integrins differentially control extravasation of inflammatory subsets into the CNS during autoimmunity.

PNAS, 2009 Feb 10;106(6):1920-5.




Cremer S, Sixt M.

Review: Analogies in the evolution of individual and social immunity.

Philos Trans R Soc Lond B Biol Sci, 2009 Jan 12;364(1513):129-42.




 

2008


Lämmermann T, Bader BL, Monkley SJ, Worbs T, Wedlich-Söldner R, Hirsch K, Keller M, Förster R, Critchley DR, Fässler R, Sixt M.

Rapid leukocyte migration by integrin-independent flowing and squeezing.

Nature, 2008 May 1;453(7191):51-5.




Riedl J, Crevenna AH, Kessenbrock K, Yu JH, Neukirchen D, Bista M, Bradke F, Jenne D, Holak TA, Werb Z, Sixt M*, Wedlich-Soldner R.*

Lifeact: a versatile marker to visualize F-actin.
Nat Methods, 2008 Jul;5(7):605-7.




Lämmermann T, Sixt M.

Review: The microanatomy of T-cell responses.

Immunol Rev, 2008 Feb;221:26-43.




Lokmic Z, Lämmermann T, Sixt M, Cardell S, Hallmann R, Sorokin L.

Review: The extracellular matrix of the spleen as a potential organizer of immune cell compartments.

Semin Immunol, 2008 Feb;20(1):4-13.




Kessenbrock K, Fröhlich L, Sixt M, Lämmermann T, Pfister H, Bateman A, Belaaouaj A, Ring J, Ollert M, Fässler R, Jenne DE. 

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.

J Clin Invest, 2008 Jul;118(7):2438-47.


Frommhold D, Ludwig A, Bixel MG, Zarbock A, Babushkina I, Weissinger M, Cauwenberghs S, Ellies LG, Marth JD, Beck-Sickinger AG, Sixt M, Lange-Sperandio B, Zernecke A, Brandt E, Weber C, Vestweber D, Ley K, Sperandio M.

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation.

J Exp Med, 2008 Jun 9;205(6):1435-46.




Tripp C, Haid B, Flacher V, Sixt M, Peter H, Farkas J, Gschwentner R, Sorokin L, Romani N, Stoitzner P.

The lymph vessel network in mouse skin visualized with antibodie against the hyaluronan receptor LYVE.

Immunobiology, 2008 213(9-10):715-28.




 

2007




Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson S, Shulman Z, Hartmann T, Sixt M, Cyster JG, Alon R.

Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces.

Nat Immunol, 2007 Oct;8(10):1076-85.




Dorn T, Kuhn U, Bungartz G, Stiller S, Bauer M, Ellwart J, Peters T, Scharffetter-Kochanek K, Semmrich M, Laschinger M, Holzmann B, Klinkert WE, Straten PT, Køllgaard T, Sixt M, Brakebusch C.

RhoH is important for positive thymocyte selection and T-cell receptor signaling.

Blood, 2007 Mar 15;109(6):2346-55.




 

2006



Sixt M, Bauer M, Lämmermann T, Fässler R.


Review: Beta1 integrins: zip codes and signaling relay for blood cells.


Curr Opin Cell Biol, 2006 Oct;18(5):482-90.





Drumea-Mirancea M, Wessels JT, Müller CA, Essl M, Eble JA, Tolosa E, Koch M, Reinhardt DP, Sixt M, Sorokin L, Stierhof YD, Schwarz H, Klein G.


Characterization of a conduit system containing laminin-5 in the human thymus: a potential transport system for small molecules.


J Cell Sci, 2006 Apr 1;119(Pt 7):1396-405.





Chu H, Thievessen I, Sixt M, Lämmermann T, Waisman A, Braun A, Noegel AA, Fässler R.


Gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response.


Mol Cell Biol, 2006 Mar;26(5):1817-25.




 

2005





Sixt M, Kanazawa N, Selg M, Samson T, Roos G, Reinhardt DP, Pabst R, Lutz MB, Sorokin L.

The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node.

Immunity, 2005 Jan;22(1):19-29.




 

2004


Zhang H, Baader S, Sixt M, Kappler J, Rauch U.

Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells.

J Histochem Cytochem, 2004 Jul;52(7):915-22.




Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D'Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur AS.

HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane.

Mol Cell, 2004 May 28;153(5):933-46.




 

2001




Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM.

Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis.

J Cell Biol, 2001 May 28;153(5):933-46.




Sixt M, Hallmann R, Wendler O, Scharffetter-Kochanek K, Sorokin LM.

Cell adhesion and migration properties of beta 2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation.

J Biol Chem, 2001 Jun 1;276(22):18878-87.




Wolf D, Hallmann R, Sass G, Sixt M, Küsters S, Fregien B, Trautwein C, Tiegs G.

TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis.

J Immunol, 2001 Jan 15;166(2):1300-7.