May 21, 2019
Function and Regulation of Centrosomes during Immune Responses
Date: May 21, 2019 |
1:30 pm –
Speaker: Eva Kiermaier, University of Bonn
Location: Mondi Seminar Room 2, Central Building
Similarly to cancer cell, primary dendritic cells, which are the most potent antigen presenting cells of the innate immune system, exhibit an increased number of centrosomes. Excess centrosomes cluster during migration and pharmacological induction of centrosome de-clustering leads to polarization defects and loss of directed cell migration.
Our data indicate that amplified centrosomes are not only a marker for malignancy but actually promote immune cell effector functions such as antigen presentation and T cell activation.
We are further interested in the molecular basis of how amplified centrosomes enhance immune responses, which will critically impact the use of centrosome-based cancer therapies.