de Bono Group

Genes, Circuits, and Behavior

The De Bono Group seeks to discover and then dissect basic molecular mechanisms that underpin the functions of neurons and neural circuits. Neurons are highly specialized cells and many fundamental questions about their organization, function and plasticity remain unaddressed.

They initiate many of their studies in C. elegans, because of its advantages for molecular and cellular neuroscience. They can identify and visualize each neuron of this animal in vivo, selectively manipulate it using transgenes, and monitor its activity with genetically-encoded sensors. Powerful genetics and advanced genomic resources make high-throughput forward genetics and single neuron profiling possible. They can also complement their genetics with excellent biochemistry, to get at molecular mechanisms that are usually conserved from the worm to man. They aim to take discoveries made in the worm into mammalian models.

To achieve their goals they are deconstructing global animal states in molecular and circuitry terms. An animal state is a coordinated response to a threat (e.g. predators) or opportunity (e.g. a potential mate). Such states arise from dynamically reconfigured neural circuits that optimize the response to the situation encountered. Hallmarks include a change in arousal, rearranged responsiveness to sensory cues, and altered physiology, with effects that often outlast the evoking stimulus.

Group Leader


On this site:


Team

Avatar

Niko Amin-Wetzel

Postdoc

Avatar

Murat Artan

Postdoc

+43 2243 9000 2171

Avatar

Stephen Barratt

Predoctoral Visiting Scientist


Avatar

Ekaterina Lashmanova

Project Technician

+43 2243 9000 2171

Avatar

Michaela Misova

PhD Student

+43 2243 9000 7421

Avatar

Nelson Ramirez Suarez

Postdoc

+43 2243 9000 2171


Avatar

Hanna Schön

PhD Student

Avatar

Yvonne Vallis

Laboratory Technician

+43 2243 9000 2171

Avatar

Giulio Valperga

Postdoc

+43 2243 9000 2171


Avatar

Thi Vuong

Postdoc

+43 2243 9000 2171


Current Projects


Publications

Flynn SM, Chen C, Artan M, Barratt S, Crisp A, Nelson GM, Peak-Chew SY, Begum F, Skehel M, de Bono M. 2020. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Nature Communications. 11. View

Beets I, Zhang G, Fenk LA, Chen C, Nelson GM, Félix M-A, de Bono M. 2020. Natural variation in a dendritic scaffold protein remodels experience-dependent plasticity by altering neuropeptide expression. Neuron. 105(1), 106–121.e10. View

Olofsson B, de Bono M. 2008. Sleep: dozy worms and sleepy flies. Current Biology. 18(5), R204–R206. View

View All Publications

Career

2019 Professor, IST Austria
2004–2019 Tenured Group Leader, MRC Laboratory of Molecular Biology, Cambridge, UK
1999–2004 Tenure-track Group Leader, MRC Laboratory of Molecular Biology, Cambridge, UK
1997–1999 Research Associate Howard Hughes Medical Institute, UCSF, San Francisco, USA
1995–1997 Wellcome Trust Travelling Prize Fellow, UCSF, San Francisco, USA
1995 PhD, University of Cambridge, UK


Selected Distinctions

2018 Wellcome Investigator Award
2011 Advanced Grant ERC
2014 Honorary Appointment, Garvan Medical Institute, Australia
2011 CoEN Award (Centre of Excellence in Neurodegeneration)
2006 Human Frontiers Science Program Organization grant
2007 Elected to EMBO
2005 The Balfour Lecture, The Genetics Society, UK
2004 Max Perutz Prize, MRC Laboratory of Molecular Biology
1995 Wellcome Trust Prize Fellowship
1990 Wellcome Trust Prize Studentship
1990 Research Studentship, Trinity College, University of Cambridge


Additional Information

Download CV



Back to Top