Hannezo Group
Physical Principles in Biological Systems
During embryo development, cells must “know” how to behave at the right place and at the right time. The Hannezo group applies methods from theoretical physics to understand how these robust choices occur.
The Hannezo group is particularly interested in design principles and processes of self-organization in biology, at various scales, in close collaboration with cell and developmental biologists. Their methods include tools from solid and fluid mechanics, statistical physics as well as soft matter approaches. Examples of problems that the group is working on – at three different scales – include: 1) how do cytoskeletal elements, which generate forces within cells, self-organize to produce complex spatio-temporal patterns? 2) how do cells concomitantly acquire identities and shape a tissue during development? and 3) how does complex tissue architecture derive from simple self-organizing principles, for instance during branching morphogenesis (in organs such as the kidneys, mammary glands, pancreas, and prostate) as a prototypical example.
Group Leader
Administrative Support
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Team
Current Projects
Stochastic branching in mammalian organs | Active fluids and cell cytoskeleton | Models of fate choices of stem cells during homeostasis and embryo development
Publications
Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J, Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Physical biology. 18(4), 041501. View
Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. 2021. Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell. 184(7), 1914–1928.e19. View
Dobramysl U, Jarsch IK, Inoue Y, Shimo H, Richier B, Gadsby JR, Mason J, Szałapak A, Ioannou PS, Correia GP, Walrant A, Butler R, Hannezo EB, Simons BD, Gallop JL. 2021. Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation. The Journal of Cell Biology. 220(4), e202003052. View
Hankeova S, Salplachta J, Zikmund T, Kavkova M, Van Hul N, Brinek A, Smekalova V, Laznovsky J, Dawit F, Jaros J, Bryja V, Lendahl U, Ellis E, Nemeth A, Fischler B, Hannezo EB, Kaiser J, Andersson ER. 2021. DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for alagille syndrome. eLife. 10, e60916. View
Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. 2021. Theory of mechanochemical patterning and optimal migration in cell monolayers. Nature Physics. 17, 267–274. View
Career
since 2017 Assistant Professor, IST Austria
2015 – 2017 Sir Henry Wellcome Postdoctoral Fellow, Gurdon Institute, Cambridge, UK
2015 – 2017 Junior Research Fellow, Trinity College, University of Cambridge, UK
2014 Postdoc, Institut Curie, Paris, France
2014 PhD, Institut Curie and Université Pierre et Marie Curie, Paris, France
Selected Distinctions
2019 EMBO Young Investigator Award
2019 ERC Starting Grant
2015 Wellcome Trust Fellowship
2014 Young Researcher Prize of the Bettencourt-Schuller Foundation
2014 Trinity College Junior Research Fellowship
2010 PhD grant from the French Ministry of Research
Additional Information
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