Heisenberg Group

Morphogenesis in Development

The most elaborate shapes of multicellular organisms – the elephant’s trunk, the orchid blossom, the lobster’s claw – all start off from a simple bunch of cells. This transformation of a seemingly unstructured cluster of cells into highly elaborate shapes is a common and fundamental principle in cell and developmental biology and the focus of the Heisenberg group’s work.

To gain insights into critical processes by which the developing organism takes shape, the Heisenberg group focuses on gastrulation in zebrafish and ascidians, a highly conserved process in which a seemingly unstructured blastula is transformed into an organized embryo. The group has chosen a transdisciplinary approach, employing a combination of genetic, cell biological, biochemical, and biophysical tools. Using these tools, the group is addressing how the interplay between the physical processes driving cell and tissue morphogenesis and the gene regulatory pathways determining cell fate specification control gastrulation. Insights derived from this work may ultimately have implications for the study of wound healing and cancer biology, as immune and cancer cells share many morphogenetic properties of embryonic cells.


On this site:


Team

Avatar

Feyza Arslan

PhD Student

Avatar

Madison Bolger-Munro

Postdoc

Avatar

Silvia Caballero Mancebo

PhD Student


Avatar

Naoya Hino

Postdoc

Avatar

Karla Huljev

PhD Student

Avatar

Tushna Kapoor

Predoctoral Visiting Scientist


Avatar

Nikhil Mishra

Postdoc

Avatar

Suyash Naik

PhD Student

Avatar

Diana Nunes Pinheiro

Postdoc


Avatar

Oleksandr Ostrenko

Postdoc

Avatar

Kornelija Pranjic-Ferscha

Laboratory Technician

Avatar

Alexandra Schauer

PhD Student


Avatar

Shayan Shamipour

Postdoc

+43 2243 9000 4781

Avatar

Gayathri Singaraju

Postdoc

Avatar

Irene Steccari

Project Technician

+43 22 439000 7452


Avatar

Ste Tavano

Postdoc

Avatar

Xin Tong

PhD Student


Current Projects

Cell adhesion | Actomyosin contraction | Cell and tissue morphogenesis | Cell polarization and migration


Publications

Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. 2021. Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell. 184(7), 1914–1928.e19. View

Xia P, Heisenberg C-PJ. 2021.Quantifying tissue tension in the granulosa layer after laser surgery. In: Germline Development in the Zebrafish. Methods in Molecular Biology, vol. 2218, 117–128. View

Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 17(1). View

Shamipour S, Caballero Mancebo S, Heisenberg C-PJ. 2021. Cytoplasm’s got moves. Developmental Cell. 56(2), P213-226. View

Godard BG, Dumollard R, Munro E, Chenevert J, Hebras C, Mcdougall A, Heisenberg C-PJ. 2020. Apical relaxation during mitotic rounding promotes tension-oriented cell division. Developmental Cell. 55(6), 695–706. View

View All Publications

Career

since 2010 Professor, IST Austria
2001 – 2010 Group Leader, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
1997 – 2000 Postdoc, University College London, UK
1996 PhD, Max Planck Institute of Developmental Biology, Tübingen, Germany


Selected Distinctions


2019 Carus Medal, German Academy of Sciences Leopoldina
2017 ERC Advanced Grant
2017 Lower Austrian Science Award
2015 Member, EMBO
2015 Member, German Academy of Sciences Leopoldina
2000 Emmy Noether Junior Professorship


Additional Information

Download CV
Open group website



Back to Top