Hippenmeyer Group

Genetic Dissection of Cerebral Cortex Development

The human cerebral cortex, the seat of our cognitive abilities, is composed of an enormous number and diversity of neurons and glia cells. How the cortex arises from neural stem cells is an unsolved but fundamental question in neuroscience. In the pursuit of mechanistic insights, the Hippenmeyer group genetically dissects corticogenesis at unprecedented single cell resolution using the unique MADM (Mosaic Analysis with Double Markers) technology.

The Hippenmeyer group’s current objectives are 1) to establish a definitive quantitative and mechanistic model of cortical neural stem cell lineage progression; 2) to dissect the cellular and molecular mechanisms generating cell-type diversity; 3) to determine the role of genomic imprinting, an epigenetic phenomenon, in cortex development. In a broader context, the group’s research has the ultimate goal to advance the general understanding of brain function and why human brain development is so sensitive to disruption of particular signaling pathways in pathological neurodevelopmental diseases and psychiatric disorders


On this site:


Team

Image of Nicole Amberg

Nicole Amberg

Postdoc

Image of Raquel Casado Polanco

Raquel Casado Polanco

PhD Student

Image of Giselle Cheung

Giselle Cheung

Postdoc


Image of Ishita Gupta

Ishita Gupta

PhD Student

Image of Andi Hansen

Andi Hansen

Postdoc

Image of Osvaldo Miranda Romero

Osvaldo Miranda Romero

PhD Student


Image of Florian Pauler

Florian Pauler

Research Technician

Image of Melissa Stouffer

Melissa Stouffer

Postdoc

Image of Carmen Streicher

Carmen Streicher

Research Technician

+43 2243 9000 7434


Image of Ana Villalba Requena

Ana Villalba Requena

Postdoc


Current Projects

Determine neuronal lineages by clonal analysis | Mechanisms generating cell-type diversity | Probing genomic imprinting in cortex development


Publications

Assen FP, Abe J, Hons M, Hauschild R, Shamipour S, Kaufmann W, Costanzo T, Krens G, Brown M, Ludewig B, Hippenmeyer S, Heisenberg C-PJ, Weninger W, Hannezo EB, Luther SA, Stein JV, Sixt MK. 2022. Multitier mechanics control stromal adaptations in swelling lymph nodes. Nature Immunology. View

Hansen AH, Pauler F, Riedl M, Streicher C, Heger A-M, Laukoter S, Sommer CM, Nicolas A, Hof B, Tsai LH, Rülicke T, Hippenmeyer S. 2022. Tissue-wide effects override cell-intrinsic gene function in radial neuron migration. Oxford Open Neuroscience. 1(1), kvac009. View

Schaaf ZA, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis KS. 2022. WDFY3 mutation alters laminar position and morphology of cortical neurons. Molecular Autism. 13, 27. View

Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. 2022. Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical development. Cell Systems. 13(6), 438–453.e5. View

Cheung GT, Bataveljic D, Visser J, Kumar N, Moulard J, Dallérac G, Mozheiko D, Rollenhagen A, Ezan P, Mongin C, Chever O, Bemelmans AP, Lübke J, Leray I, Rouach N. 2022. Physiological synaptic activity and recognition memory require astroglial glutamine. Nature Communications. 13, 753. View

View All Publications

ReX-Link: Simon Hippenmeyer


Career

since 2019 Professor, Institute of Science and Technology Austria (ISTA)
2012 – 2019 Assistant Professor, Institute of Science and Technology Austria (ISTA)
2011 – 2012 Research Associate, Stanford University, Palo Alto, USA
2006 – 2011 Postdoctoral Fellow, Stanford University, Palo Alto, USA
2004 – 2006 Postdoctoral Associate, University of Basel and Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2004 PhD, University of Basel, Switzerland


Selected Distinctions

2016 ERC Consolidator Grant
2014 HFSP Program Grant
2013 Marie Curie Career Integration Grant
2009 – 2011 Fellowship for Advanced Researchers, Swiss National Science Foundation, Bern, Switzerland
2007 – 2009 HFSP Long-term Fellowship
2006 EMBO Long-term Fellowship
2005 Natural Sciences Faculty Prize for the best PhD thesis of the year
2004, University of Basel, Switzerland
2005 Edmond H. Fischer Prize


Additional Information

Download CV
Open Hippenmeyer group website



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