LIFE SCIENCES

Shigemoto Group

Molecular Neuroscience

Information transmission, the formation of memory, and plasticity are all controlled by various molecules at work in the brain. Focusing on the localization and distribution of molecules in brain cells, the Shigemoto group investigates their functional roles in higher brain functions.

The release of neurotransmitters from a nerve cell into the synapse, where they act on receptors on the connecting nerve cell, is the primary process of information transmission and computation in the brain. The Shigemoto group studies the localization of single neurotransmitter receptors, ion channels, and other functional molecules to understand the molecular basis of neuronal information processing. The group has pioneered several methods for studying the localization of functional molecules at an unprecedented sensitivity, detecting and visualizing even single membrane proteins in nerve cells using SDS-digested freeze-fracture replica labeling. They apply these methods to investigate the mechanisms of signaling and plasticity in the brain, with questions ranging from neurotransmission to learning.

Group Leader


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Team

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Catarina Alcarva

PhD Student

+43 2243 9000 2090

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Pradeep Bhandari

PhD Student

+43 2243 9000 5204

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Matthew Case

Postdoc

+43 2243 9000 5205


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Kohgaku Eguchi

Postdoc

+43 2243 90007631 0

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Felipe Fredes Tolorza

Postdoc

+43 2243 9000 7631

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Elena Hollergschwandtner

Laboratory Technician


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Marijo Jevtic

PhD Student

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David Kleindienst

PhD Student

+43 2243 9000 7630

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Peter Koppensteiner

Postdoc


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Elodie Le Monnier

Laboratory Technician

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Jacqueline-Claire Montanaro-Punzengruber

Senior Laboratory Technician

+43 2243 9000 7631

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Maria Silva Sifuentes

Laboratory Technician


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Cihan Önal

PhD Student


Current Projects

Ultrastructural localization and function of receptors and ion channels in the brain | Mechanisms of long-term memory formation | Left-right asymmetry of hippocampal circuitry


Publications

Luján R, Aguado C, Ciruela F, Arus X, Martín Belmonte A, Alfaro Ruiz R, Martinez Gomez J, De La Ossa L, Watanabe M, Adelman J, Shigemoto R, Fukazawa Y. 2018. Sk2 channels associate with mGlu1α receptors and CaV2.1 channels in Purkinje cells. Frontiers in Cellular Neuroscience. 12. View

Reipert S, Goldammer H, Richardson C, Goldberg M, Hawkins T, Hollergschwandtner E, Kaufmann W, Antreich S, Stierhof Y. 2018. Agitation modules: Flexible means to accelerate automated freeze substitution. Journal of Histochemistry and Cytochemistry. View

Case MJ. 2018. From the left to the right: A tale of asymmetries, environments, and hippocampal development, IST Austria, 186p. View

Miklosi A, Del Favero G, Bulat T, Höger H, Shigemoto R, Marko D, Lubec G. 2018. Super resolution microscopical localization of dopamine receptors 1 and 2 in rat hippocampal synaptosomes. Molecular Neurobiology. 55(6), 4857 – 4869. View

Luján R, Aguado C, Ciruela F, Cózar J, Kleindienst D, De La Ossa L, Bettler B, Wickman K, Watanabe M, Shigemoto R, Fukazawa Y. 2018. Differential association of GABAB receptors with their effector ion channels in Purkinje cells. Brain Structure and Function. 223(3), 1565–1587. View

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Career

since 2013 Professor, IST Austria
1998 – 2014 Professor, National Institute for Physiological Sciences, Okazaki, Japan
1990 – 1998 Assistant Professor, Kyoto University Faculty of Medicine, Kyoto, Japan
1994 PhD, Kyoto University, Japan
1985 MD, Kyoto University Faculty of Medicine, Japan


Selected Distinctions

ISI Highly Cited Researcher
2017 Member, Academia Europaea
2016 ERC Advanced Grant
2000 ISI Citation Laureate Award


Additional Information

Download CV

ERC Advanced Grant website



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