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Saric Group

Computational Soft and Living Matter

How do lifeless molecules create living organisms? How can such processes fail, resulting in diseases? At the intersection of soft matter physics, molecular cell biology, and physical chemistry, the Saric group studies physical mechanisms behind non-equilibrium self-organization of biomolecules in healthy and diseased states.

Currently, the group is focused on investigating the physical principles of cellular reshaping and cell division across evolution, and on the formation of pathological protein aggregates in the context of neurodegenerative diseases. Saric group develops computational models rooted in soft matter and statistical physics, which are powerful in traversing scales and investigating collective phenomena. The group closely collaborates with experimental colleagues on a range of systems, from synthetic set-ups to living cells.


Image of Samo Curk

Samo Curk

Predoctoral Visiting Scientist

Image of Kevin Klein

Kevin Klein

Predoctoral Visiting Scientist

Image of Juraj Majek

Juraj Majek

PhD Student

Image of Billie Meadowcroft

Billie Meadowcroft

Predoctoral Visiting Scientist

Image of Maitane Muñoz-Basagoiti

Maitane Muñoz-Basagoiti


Image of Adam Prada

Adam Prada


Image of Mau Rojas Vega

Mau Rojas Vega

PhD Student

Image of Miguel Santana de Freitas Amaral

Miguel Santana de Freitas Amaral

PhD Student

Image of Valerio Sorichetti

Valerio Sorichetti


Image of Christian Vanhille Campos

Christian Vanhille Campos

Predoctoral Visiting Scientist

Current Projects

Non-equilibrium protein assembly: from building blocks to biological machines | The evolution of trafficking: from archaea to eukaryotes | Collagen assembly: from molecules to fibrils | How do you build a wall? Mechanistic principles of bacterial division septum building | Cell division and repair by ESCRT-III filaments


Giubertoni G, Feng L, Klein K, Giannetti G, Rutten L, Choi Y, Van Der Net A, Castro-Linares G, Caporaletti F, Micha D, Hunger J, Deblais A, Bonn D, Sommerdijk N, Šarić A, Ilie IM, Koenderink GH, Woutersen S. 2024. Elucidating the role of water in collagen self-assembly by isotopically modulating collagen hydration. Proceedings of the National Academy of Sciences of the United States of America. 121(11), e2313162121. View

Curk S, Krausser J, Meisl G, Frenkel D, Linse S, Michaels TCT, Knowles TPJ, Šarić A. 2024. Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America. 121(7), e2220075121. View

Azadbakht A, Meadowcroft B, Majek J, Šarić A, Kraft DJ. Nonadditivity in interactions between three membrane-wrapped colloidal spheres. Biophysical Journal. View

Sakref Y, Muñoz Basagoiti M, Zeravcic Z, Rivoire O. 2023. On kinetic constraints that catalysis imposes on elementary processes. The Journal of Physical Chemistry B. 127(51), 10950–10959. View

Curk S. 2023. aggregation_data, Figshare. View

View All Publications

ReX-Link: Anđela Šarić


Since 2023 Professor, Institute of Science and Technology Austria (ISTA)
Since 2023 Honorary Professor of Physics, University College London, UK
2022 – 2023 Assistant Professor, Institute of Science and Technology Austria (ISTA)
2019 – 2022 Associate Professor of Physics, University College London, UK
2016 – 2019 Junior Group Leader in Physics, University College London, UK
2013 – 2016 HFSP Postdoctoral Fellow and Emmanuel College Junior Research Fellow, University of Cambridge, UK
2013 PhD, Columbia University in New York, USA

Selected Distinctions

2023 Soft Matter Lectureship
2023 Vallee Foundation Fellowship
2022 Biophysical Society Paper of the Year Award
2021 EMBO Young Investigator Award
2018 ERC Starting Grant
2017 Royal Society University Research Fellowship
2013 HFSP Postdoctoral Fellowship
2013 The Hammet outstanding PhD Thesis Award, Columbia University

Additional Information

View Andela Saric’s lab
Physics & Beyond at ISTA

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