Shigemoto Group

Molecular Neuroscience

Information transmission, the formation of memory, and plasticity are all controlled by various molecules at work in the brain. Focusing on the localization and distribution of molecules in brain cells, the Shigemoto group investigates their functional roles in higher brain functions.

The release of neurotransmitters from a nerve cell into the synapse, where they act on receptors on the connecting nerve cell, is the primary process of information transmission and computation in the brain. The Shigemoto group studies the localization of single neurotransmitter receptors, ion channels, and other functional molecules to understand the molecular basis of neuronal information processing. The group has pioneered several methods for studying the localization of functional molecules at an unprecedented sensitivity, detecting and visualizing even single membrane proteins in nerve cells using SDS-digested freeze-fracture replica labeling. They apply these methods to investigate the mechanisms of signaling and plasticity in the brain, with questions ranging from neurotransmission to learning.


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Team

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Catarina Alcarva

PhD Student

+43 2243 9000 2090

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Pradeep Bhandari

Postdoc

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Jessica Coelho Gaspar

Postdoc


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Kohgaku Eguchi

Postdoc

+43 2243 90007631 0

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Muhammad Jahirul Islam

Postdoc

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David Kleindienst

Postdoc

+43 2243 9000 7630


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Peter Koppensteiner

Postdoc

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Hana Korinkova

PhD Student

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Elodie Le Monnier

Research Technician


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Jacqueline-Claire Montanaro-Punzengruber

Research Technician

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Elena Säckl

Research Technician

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Cihan Önal

PhD Student


Current Projects

New chemical labeling methods for high resolution EM visualization of single molecules | Ultrastructural localization and function of receptors and ion channels in the brain | Mechanisms of long-term memory formation | Left-right asymmetry of hippocampal circuitry


Publications

Jevtic M. 2022. Contextual fear learning induced changes in AMPA receptor subtypes along the proximodistal axis in dorsal hippocampus. ISTA. View

Hori T, Eguchi K, Wang HY, Miyasaka T, Guillaud L, Taoufiq Z, Mahapatra S, Yamada H, Takei K, Takahashi T. 2022. Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model. eLife. 11, e73542. View

Thayyil S, Nishigami Y, Islam MJ, Hashim PK, Furuta K, Oiwa K, Yu J, Yao M, Nakagaki T, Tamaoki N. 2022. Dynamic control of microbial movement by photoswitchable ATP antagonists. Chemistry – A European Journal., e202200807. View

Shigemoto R. 2022. Electron microscopic visualization of single molecules by tag-mediated metal particle labeling. Microscopy. 71(Supplement_1), i72–i80. View

Eguchi K, Montanaro-Punzengruber J-C, Le Monnier E, Shigemoto R. 2022. The number and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals. Frontiers in Neuroanatomy. 16, 846615. View

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ReX-Link: Ryuichi Shigemoto


Career

since 2013 Professor, Institute of Science and Technology Austria (ISTA)
1998 – 2014 Professor, National Institute for Physiological Sciences, Okazaki, Japan
1990 – 1998 Assistant Professor, Kyoto University Faculty of Medicine, Kyoto, Japan
1994 PhD, Kyoto University, Japan
1985 MD, Kyoto University Faculty of Medicine, Japan


Selected Distinctions

ISI Highly Cited Researcher
2017 Member, Academia Europaea
2016 ERC Advanced Grant
2000 ISI Citation Laureate Award


Additional Information

Download CV

ERC Advanced Grant website



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