Shigemoto Group

Molecular Neuroscience

Information transmission, the formation of memory, and plasticity are all controlled by various molecules at work in the brain. Focusing on the localization and distribution of molecules in brain cells, the Shigemoto group investigates their functional roles in higher brain functions.

The release of neurotransmitters from a nerve cell into the synapse, where they act on receptors on the connecting nerve cell, is the primary process of information transmission and computation in the brain. The Shigemoto group studies the localization of single neurotransmitter receptors, ion channels, and other functional molecules to understand the molecular basis of neuronal information processing. The group has pioneered several methods for studying the localization of functional molecules at an unprecedented sensitivity, detecting and visualizing even single membrane proteins in nerve cells using SDS-digested freeze-fracture replica labeling. They apply these methods to investigate the mechanisms of signaling and plasticity in the brain, with questions ranging from neurotransmission to learning.

Group Leader


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Team

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Catarina Alcarva

PhD Student

+43 2243 9000 2090

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Matthew Case

Postdoc

+43 2243 9000 5205

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Jessica Coelho Gaspar

Postdoc


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Kohgaku Eguchi

Postdoc

+43 2243 90007631 0

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Elena Hollergschwandtner

Laboratory Technician

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Muhammad Jahirul ISLAM

Postdoc


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Marijo Jevtic

PhD Student

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David Kleindienst

PhD Student

+43 2243 9000 7630

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Tsuneyuki Koga

Postdoc


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Peter Koppensteiner

Postdoc

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Jacqueline-Claire Montanaro-Punzengruber

Senior Laboratory Technician

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Cihan Önal

PhD Student


Current Projects

New chemical labeling methods for high resolution EM visualization of single molecules | Ultrastructural localization and function of receptors and ion channels in the brain | Mechanisms of long-term memory formation | Left-right asymmetry of hippocampal circuitry


Publications

Piriya Ananda Babu L, Wang HY, Eguchi K, Guillaud L, Takahashi T. 2020. Microtubule and actin differentially regulate synaptic vesicle cycling to maintain high-frequency neurotransmission. The Journal of neuroscience. 40(1), 131–142. View

Tabata S, Jevtic M, Kurashige N, Fuchida H, Kido M, Tani K, Zenmyo N, Uchinomiya S, Harada H, Itakura M, Hamachi I, Shigemoto R, Ojida A. 2019. Electron microscopic detection of single membrane proteins by a specific chemical labeling. iScience. 22(12), 256–268. View

Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R. 2019. Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses. FASEB journal. 33(12), 13734–13746. View

Kasugai Y, Vogel E, Hörtnagl H, Schönherr S, Paradiso E, Hauschild M, Göbel G, Milenkovic I, Peterschmitt Y, Tasan R, Sperk G, Shigemoto R, Sieghart W, Singewald N, Lüthi A, Ferraguti F. 2019. Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning. Neuron. 104(4), 781–794.e4. View

Martín-Belmonte A, Aguado C, Alfaro-Ruíz R, Moreno-Martínez AE, De La Ossa L, Martínez-Hernández J, Buisson A, Früh S, Bettler B, Shigemoto R, Fukazawa Y, Luján R. 2019. Reduction in the neuronal surface of post and presynaptic GABA>B< receptors in the hippocampus in a mouse model of Alzheimer’s disease. Brain Pathology. View

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Career

since 2013 Professor, IST Austria
1998 – 2014 Professor, National Institute for Physiological Sciences, Okazaki, Japan
1990 – 1998 Assistant Professor, Kyoto University Faculty of Medicine, Kyoto, Japan
1994 PhD, Kyoto University, Japan
1985 MD, Kyoto University Faculty of Medicine, Japan


Selected Distinctions

ISI Highly Cited Researcher
2017 Member, Academia Europaea
2016 ERC Advanced Grant
2000 ISI Citation Laureate Award


Additional Information

Download CV

ERC Advanced Grant website



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