Morphogenesis in Development

Carl-Philipp Heisenberg

Carl-Philipp Heisenberg studies the molecular and cellular mechanisms by which vertebrate embryos take shape. To obtain insights into critical processes in vertebrate morphogenesis, such as cell adhesion, migration, and polarization, the Heisenberg group focuses on gastrulation movements in zebrafish. Gastrulation is a highly conserved morphogenetic process describing the transformation of a seemingly unstructured blastula into a highly organized gastrula-stage embryo composed of the three germ layers ectoderm, mesoderm and endoderm. Zebrafish is an ideal organism to study gastrulation movements as embryos develop outside of the mother and are easily accessible for both experimental and genetic manipulations. To analyze gastrulation movements, the Heisenberg group uses a multi-disciplinary approach employing a combination of genetic, cell biological, biochemical and biophysical techniques. Utilizing these different experimental tools, they are unraveling the molecular and cellular mechanisms underlying zebrafish gastrulation movements.

Contact
Carl-Philipp Heisenberg
Institute of Science and Technology Austria (IST Austria)
Am Campus 1
A – 3400 Klosterneuburg

Phone: +43 (0)2243 9000-3901
E-mail: heisenberg@remove-this.ist.ac.at

CV and publication list

Heisenberg Group website

Assistant
Nicole Hotzy

Phone: +43 (0)2243 9000-1032
E-mail: nicole.hotzy@remove-this.ist.ac.at

Team

  • Vanessa Barone, PhD Student
  • Daniel Capek, PhD Student
  • Julien Compagnon, Postdoc
  • Benoit Godard, Postdoc
  • Roland Kardos, Postdoc
  • Gabby Krens, Postdoc
  • Hitoshi Morita, Postdoc
  • Kornelija Pranjic-Ferscha, Technician
  • Verena Ruprecht, Joint Postdoc with Sixt Group
  • Keisuke Sako, Postdoc
  • Philipp Schmalhorst, Postdoc
  • Cornelia Schwayer, PhD Student
  • Mateusz Sikora, Postdoc
  • Jana Slovakova, Postdoc
  • Michael Smutny, Postdoc

Current Projects

  • Cell adhesion
  • Actomyosin contractility and morphogensis
  • Cell polarization

Selected Publications

  • Campinho P, Behrndt M, Ranft J, Risler T, Minc N, Heisenberg CP. 2013. Nature Cell Biology 15, 1405-141.
  • Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, Grill S, Heisenberg CP. 2012. Forces driving epithelial spreading in zebrafish gastrulation. Science  338(6104):257-260.
  • Maitre JL, Berthoumieux H, Krens SF, Salbreux G, Juelicher F, Paluch E,  Heisenberg CP. 2012. Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells. Science. 338(6104):253-256.

Career
Since 2010 Professor, IST Austria
2001– 2010 Group Leader, Max-Planck Institute, Dresden, Germany
1997– 2000 Postdoc, University College London, UK
1993–1996  PhD, Max-Planck Institute, Tübingen, Germany

Selected Distinctions

2000 Emmy Noether Junior Professorship
1998 Marie-Curie Postdoctoral Fellowship
1997 EMBO Postdoctoral Fellowship

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