High-resolution Optical Imaging for Biology

The central aim of the Danzl lab, starting in early 2017, will be to shed light on problems of biological and ultimately also medical relevance using a set of advanced light microscopy tools.

In terms of microscopy, the emphasis will be on approaches that are not limited in their spatial resolving power by the diffraction of light waves. This diffraction resolution limit entails a maximally achievable resolution of ~200 nm for conventional light microscopy. Diffraction-unlimited methods with a resolution of tens of nanometres allow capturing more details of biological specimens than conventional light microscopy approaches.

Analysing living cells and tissues at high spatial and temporal resolution in a minimally perturbative way poses a significant challenge. To this aim, we will engage in the development of novel imaging approaches, building on our expertise both in fundamental physics and in high-resolution imaging, and we will integrate the imaging with the latest technologies to manipulate cells and tissues and to label them for imaging.

The biologists in our interdisciplinary group will thus be able to directly employ highest performance optical microscopes tailor-made for addressing a specific biological problem while the physicists/engineers in the group will enjoy their developments being driven by biological problems and finding immediate application. 

Johann Georg Danzl
Institute of Science and Technology Austria (IST Austria)
Am Campus 1
A – 3400 Klosterneuburg

Email: johann.danzl@remove-this.ist.ac.at

CV and publication list


Rita Six

Phone: +43 (0)2243 9000-1165
E-mail: rita.six@remove-this.ist.ac.at

Job Openings

The group has currently openings for postdocs with a physics or biology background (or related disciplines), PhD students, and undergraduate student interns.

Selected Publications

  • Coordinate-targeted fluorescence nanoscopy with multiple off-states. J.G. Danzl*+, S.C. Sidenstein*, C. Gregor, N. Urban, P. Ilgen, S. Jakobs, S.W. Hell+. Nature Photonics 10, 122 (2016). +corresponding authors,*equal contribution. Highlighted in Nature Methods 13, 196 (2016). Nature Photonics cover 02/2016.
  • An ultracold high-density sample of rovibronic ground-state molecules in an optical lattice. J.G. Danzl+, M.J. Mark, E. Haller, M. Gustavsson, R. Hart, J. Aldegunde, J. M. Hutson und H.-C. Nägerl+. Nature Physics 6, 265 (2010). +corresponding authors.
  • Quantum gas of deeply bound ground state molecules. J. G. Danzl+, E. Haller, M. Gustavsson, M. J. Mark, R. Hart, N. Bouloufa, O. Dulieu, H. Ritsch, H.-C. Nägerl. Science 321, 1062 (2008). +corresponding author.
  • Pinning quantum phase transition for a Luttinger liquid of strongly interacting bosons. E. Haller, R. Hart, M.J. Mark, J.G. Danzl, L. Reichsöllner, M. Gustavsson, M. Dalmonte, G. Pupillo, H.-C. Nägerl. Nature 466, 597 (2010).
  • Realization of an excited, strongly-correlated quantum gas phase. E. Haller, M. Gustavsson, M.J. Mark, J.G. Danzl, R. Hart, G. Pupillo, H.-C. Nägerl. Science 325, 1224 (2009).
  • Evidence for Efimov quantum states in an ultracold gas of caesium atoms. T. Kraemer, M. Mark, P. Waldburger, J.G. Danzl, C. Chin, B. Engeser, A. D. Lange, K. Pilch, A. Jaakkola, H.-C. Nägerl and R. Grimm. Nature 440, 315 (2006).


As of 2017 Assistant Professor, IST Austria
2012-2016 Postdoc, Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. Nanoscale fluorescence imaging
2010-2011 Postdoc, Institute for Experimental Physics, University of Innsbruck, Austria.
2010 PhD, Experimental Physics, University of Innsbruck, Austria. Ultracold molecular quantum gases.
2005 Medical Doctor, Medical University of Innsbruck, Austria.

Selected Distinctions

2012-2014 Marie Curie Intra-European Fellowship
2011 PhD Thesis selected as one of the 4 best PhD theses in the years 2009 and 2010 by the AMO (Atomic, Molecular, Optical) section of the German Physical Society.
2009 Liechtenstein Prize awarded by the Principality of Liechtenstein, Vaduz.
2009 Skinner Prize, Faraday Discussion 142 (Royal Society of Chemistry), Durham, England.
2006 Scholarship for intellectually highly gifted persons, Rotary Club Innsbruck, Austria.

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